Concepts and Applications of Stem Cell Biology

1. Front Matter

   Pages I-XXII

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2. Introduction: A Decade Teaching Stem Cell Biology

   • Gabriela Rodrigues

   Pages 1-9

3. Preimplantation Development: From Germ Cells to Blastocyst

   • Bernard A. J. Roelen

   Pages 11-27

4. Origins of Pluripotency: From Stem Cells to Germ Cells

   • Maria Gomes Fernandes, Susana M. Chuva de Sousa Lopes

   Pages 29-55

5. Human Induced Pluripotent Stem (hiPS) Cells: Generation and Applications

   • Christian Freund

   Pages 57-71

6. Cellular Reprogramming and Aging

   • Sandrina Nóbrega-Pereira, Bruno Bernardes de Jesus

   Pages 73-91

7. Cloning

   • Bernard A. J. Roelen

   Pages 93-113

8. Stem Cells in Plant Development

   • Beatriz Gonçalves

   Pages 115-130

9. Axial Stem Cells and the Formation of the Vertebrate Body

   • André Dias, Rita Aires

   Pages 131-158

10. Skeletal Muscle Development: From Stem Cells to Body Movement

    • Marianne Deries, André B. Gonçalves, Sólveig Thorsteinsdóttir

    Pages 159-185

11. Cardiac Regeneration and Repair: From Mechanisms to Therapeutic Strategies

    • Vasco Sampaio-Pinto, Ana C. Silva, Perpétua Pinto-do-Ó, Diana S. Nascimento

    Pages 187-211

12. Reproducing Human Brain Development In Vitro: Generating Cerebellar Neurons for Modelling Cerebellar Ataxias

    • Evguenia Bekman, Teresa P. Silva, João P. Cotovio, Rita Mendes de Almeida

    Pages 213-228

13. Neurotoxicology and Disease Modelling

    • Carolina Nunes, Marie-Gabrielle Zurich

    Pages 229-246

14. Mesenchymal Stem Cells for Cutaneous Wound Healing

    • Sérgio P. Camões, Jorge M. Santos, Félix Carvalho, Joana P. Miranda

    Pages 247-267

15. Correction to: Cellular Reprogramming and Aging

    • Gabriela Rodrigues, Bernard A. J. Roelen

    Pages C1-C1

This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal,  and several types of muscular cells, in biomedical research and clinical applications.


This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

• stem cells
• embryo
• pluripotency and reprogramming
• tissue regeneration
• genomics

• Centro de Ecologia, Evolução e Alterações Ambientais, Departamento de Biologia Animal, Faculdade de Ciências da, Universidade de Lisboa, Lisbon, Portugal

  Gabriela Rodrigues

• Embryology, Anatomy and Physiology, Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht Universtity, Utrecht, The Netherlands

  Bernard A. J. Roelen

Gabriela Rodrigues is an Assistant Professor at the University of Lisbon where she is responsible for the course on Stem Cell Biology. 

Bernard Roelen is an Associate Professor at the Department of Farm Animal Health, Faculty of Veterinary Medicine in Utrecht University whose research focus is on mammalian germ cells and early embryonic stem cells. 

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