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Advances in Experimental Medicine and Biology
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Current Advances in the Science of Osteosarcoma

Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models

Editors: Kleinerman, Eugenie S., Gorlick, Richard (Eds.)

  • Thoroughly updated and revised, the second edition is a comprehensive and in-depth look at new developments in a rapidly developing field
  • Edited by two internationally recognized, leading experts on osteosarcoma and sarcoma, the second edition will feature chapters written by a collection of internationally-based researchers
  • Provides a comprehensive and up-to-date overview of the current research on the molecular, biological and genetic characteristics of sarcoma and osteosarcoma with in-depth discussions on new developments and future directions 
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eBook $149.00
price for USA in USD (gross)
  • The eBook version of this title will be available soon
  • Due: September 25, 2020
  • ISBN 978-3-030-43085-6
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $199.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: August 28, 2020
  • ISBN 978-3-030-43084-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
About this book

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

About the authors

Eugenie S. Kleinerman, (Editor), holds the Mary V. and John A. Reilly Distinguished Chair, and is currently Professor at the University of Texas MD Anderson Cancer Center in the Departments of Pediatrics Research and Cancer Biology. Dr. Kleinerman is internationally recognized for her scientific and clinical expertise in sarcomas, particular osteosarcoma, and for pioneering the use of a unique immunotherapy agent, liposome-encapsulated MTP-PE, for patients with newly diagnosed osteosarcoma or unresponsive relapsed osteosarcoma lung metastases. Her current research interests include developing novel ways to treat sarcoma patients by identifying new therapeutic targets, the properties that influence metastases, the efficacy of dendritic cell vaccines with and without checkpoint inhibitors for osteosarcoma lung metastases, how tumor vessels are formed in Ewing sarcoma and the use of exercise interventions to mitigate chemotherapy-induced cardiotoxicity.

 Richard Gorlick, (Co-Editor), is currently the Mosbacher Pediatrics Chair of the Department of Pediatrics Patient Care, and Division Head of Pediatrics at the University of Texas MD Anderson Cancer Center. Dr. Gorlick is an internationally recognized expert in pediatric oncology and hematology, whose research and clinical work have focused on sarcomas, tumors that grow in connective tissues including bones, muscles, tendons and cartilage, understanding the mechanisms behind the development and progression of osteosarcoma, as well as targeted therapies and new drugs for childhood cancers.

Buy this book

eBook $149.00
price for USA in USD (gross)
  • The eBook version of this title will be available soon
  • Due: September 25, 2020
  • ISBN 978-3-030-43085-6
  • Digitally watermarked, DRM-free
  • Included format:
  • ebooks can be used on all reading devices
Hardcover $199.99
price for USA in USD
  • Customers within the U.S. and Canada please contact Customer Service at +1-800-777-4643, Latin America please contact us at +1-212-460-1500 (24 hours a day, 7 days a week). Pre-ordered printed titles are excluded from promotions.
  • Due: August 28, 2020
  • ISBN 978-3-030-43084-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
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Bibliographic Information

Bibliographic Information
Book Title
Current Advances in the Science of Osteosarcoma
Book Subtitle
Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models
Editors
  • Eugenie S. Kleinerman
  • Richard Gorlick
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1258
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-43085-6
DOI
10.1007/978-3-030-43085-6
Hardcover ISBN
978-3-030-43084-9
Series ISSN
0065-2598
Edition Number
2
Number of Pages
XIII, 233
Number of Illustrations
11 b/w illustrations, 23 illustrations in colour
Topics

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