AAPS Introductions in the Pharmaceutical Sciences

Pharmaco-complexity

Non-Linear Phenomena and Drug Product Development

Authors: Hickey, Anthony J, Smyth, Hugh D. C.

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  • Details the importance of non-linear interpretation for a range of pharmaceutical science topics in order to control or modulate them to improve therapeutic strategies.
  • Points out Individualized drug therapy increases the need for increasing complex interpretations of data related to drug design and delivery
  • Discusses how using AI and machine learning may speed up identification of therapeutic leads, drug product development, clinical applications, and drug repurposing
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About this book

Non-linear phenomena pervade the pharmaceutical sciences.  Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic “Pharmaco-complexity: Non-linear Phenomena and Drug Product Development”.


About the authors

Dr. Anthony Hickey is Distinguished Fellow of RTI International, the Director of the UNC Catalyst for Rare Diseases and Professor of Molecular Pharmaceutics of the Eshelman School of Pharmacy and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the American Association for the Advancement of Science, the American Association of Pharmaceutical Scientists the Royal Society of Medicine and the Royal Society of Biology. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science. Dr. Hugh Smyth is the Alan W. Hamm Centennial Fellow and Professor of Molecular Pharmaceutics and Drug Delivery at the University of Texas at Austin. He is the Editor in Chief of Drug Development and Industrial Pharmacy, a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited several volumes on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of several diseases.


Hugh D. C. Smyth is the Hamm Endowed Faculty Fellow and Professor of Pharmaceutics with Tenure, College of Pharmacy, The University of Texas at Austin. He is also an Adjunct Associate Scientist at the Lovelace Respiratory Research Institute, Albuquerque, NM. He is also the Editor in Chief of Drug Development and Industrial Pharmacy. He has over 130 peer reviewed publications, editor of 3 books, 25 book chapters, and over 20 patents or patent applications. He has a Pharmacy and a Ph.D. degree from the University of Otago, New Zealand. He was the American Association of Pharmaceutical Scientists (AAPS) New Investigator award winner for Pharmaceutics and Pharmaceutical Technologies. He also received the PhRMA Foundation New Investigator Award in pharmaceutics. His laboratory focuses on novel drug delivery systems. Dr. Smyth has started several companies resulting from technologies discovered in his laboratory including Respira Therapeutics, Nob Hill Therapeutics, and Via Therapeutics.

  

Table of contents (8 chapters)

Table of contents (8 chapters)
  • The Nature of Complexity and Relevance to Pharmaceutical Sciences

    Pages 1-4

    Hickey, Anthony J. (et al.)

  • Phenomena in Physical and Surface Chemistry

    Pages 5-16

    Hickey, Anthony J. (et al.)

  • Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation

    Pages 17-30

    Hickey, Anthony J. (et al.)

  • Considerations in Monitoring and Controlling Pharmaceutical Manufacturing

    Pages 31-38

    Hickey, Anthony J. (et al.)

  • Fractal Pharmacokinetics, Systems Pharmacology, Network Analysis, Multiscale, Kinetics, Toxicokinetics, Drug Safety

    Pages 39-45

    Hickey, Anthony J. (et al.)

Buy this book

eBook $79.99
price for USA in USD
  • ISBN 978-3-030-42783-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $99.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Pharmaco-complexity
Book Subtitle
Non-Linear Phenomena and Drug Product Development
Authors
Series Title
AAPS Introductions in the Pharmaceutical Sciences
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
American Association of Pharmaceutical Scientists
eBook ISBN
978-3-030-42783-2
DOI
10.1007/978-3-030-42783-2
Hardcover ISBN
978-3-030-42782-5
Series ISSN
2522-834X
Edition Number
2
Number of Pages
X, 70
Number of Illustrations
10 b/w illustrations, 4 illustrations in colour
Additional Information
Originally published as Volume 1 in the series Outlines in the Pharmaceutical Sciences in 2010
Topics