Advances in Experimental Medicine and Biology

Mechanisms of Genome Protection and Repair

Editors: Zharkov, Dmitry O. (Ed.)

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  • DNA repair, the topic of this book, helps each human cell to survive millions of hits damaging its genome daily
  • Covers many levels, from single proteins at an atomistic resolution to whole organisms
  • Focus on molecular mechanisms that determine how we fight – or succumb to – cancer and neurodegeneration
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  • ISBN 978-3-030-41283-8
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About this book

DNA is under constant challenge from environmental and endogenous metabolic assaults. Several layers of defence and repair systems allow cells to maintain stable genomes; in humans, dysfunction of these systems leads to cancer, neurodegeneration, and other pathologies. At the same time, recently it had emerged that targeted and regulated DNA damage and repair is a mechanism underlying several important cellular processes such as epigenetic demethylation and immunoglobulin gene diversification. The present collection of papers is aimed to cover new developments in the area of protective and regulatory mechanisms associated with DNA damage. The mechanisms ruling the recognition of damaged nucleotides against the vast background of normal ones are reviewed. The role of extended non-catalytic domains that are often found in eukaryotic DNA repair proteins in contrast to their downsized, catalytic-only bacterial counterparts is discussed. Among the proposed subjects are the regulatory functions of bulky covalent modifications such as poly(ADP)ribosylation and ubiquitylation in DNA damage response, especially in the context of chromatin remodelling. As opposed to DNA repair, damage tolerance allows cells to replicate with lesions in the genome; the enzymes responsible are also covered. Finally, we present examples of modern multilevel understanding of the cell function and malfunction in the wake of genotoxic assaults such as oxidative stress, abiotic environmental stress, and DNA-damaging plant toxins.

About the authors

Dmitriy Zharkov is the head of the Novosibirsk State University laboratory of protein engineering. He is a leading specialist in the field of fundamental mechanisms of DNA damage, DNA reparation and cell response to genotoxic stress. He has discovered several ferments of human reparation, defined special structures of some DNA-glycosylases and developed the theory of substrate specificity of ferments that recognize nucleic acids as dynamic multi-stage process. 

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix-Hairpin-Helix Structural Superfamily

    Pages 1-18

    Kuznetsov, Nikita A. (et al.)

  • Protein Engineering of DNA-Dependent Enzymes

    Pages 19-33

    Yudkina, Anna V. (et al.)

  • A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis

    Pages 35-45

    Gagarinskaya, Diana I. (et al.)

  • Impact of PARP1, PARP2 & PARP3 on the Base Excision Repair of Nucleosomal DNA

    Pages 47-57

    Kutuzov, M. M. (et al.)

  • Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling

    Pages 59-75

    Madders, Eleanor C. E. T. (et al.)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-3-030-41283-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $169.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Genome Protection and Repair
Editors
  • Dmitry O. Zharkov
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1241
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-41283-8
DOI
10.1007/978-3-030-41283-8
Hardcover ISBN
978-3-030-41282-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 220
Number of Illustrations
10 b/w illustrations, 20 illustrations in colour
Topics