NAFLD and NASH

1. Front Matter

   Pages i-x

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2. The Spectrum of NAFLD: From the Organ to the System

   • Yolanda Sanchez-Torrijos, Javier Ampuero

   Pages 1-10

3. Detection of NAFLD/NASH in the General Population and in Primary Care Clinics

   • Maya Margalit, Hanny Yeshua, Neta Gotlieb, Shira Zelber-Sagi

   Pages 11-27

4. Genes and NAFLD/NASH Progression

   • Rasha El Sharkawy, Jacob George, Mohammed Eslam

   Pages 29-47

5. Geometry of Nutrition: Nutrients and NAFLD Progression

   • Genoveva Berná, Leticia Álvarez-Amor, Franz Martín

   Pages 49-67

6. Biomarkers in Pediatric NAFLD

   • María Rubio-Murillo, Alejandro Rodríguez-Martínez

   Pages 69-88

7. Biochemical Biomarkers of NAFLD/NASH

   • Ciro Celsa, Grazia Pennisi, Federica Spatola, Aurora Giannetti, Salvatore Petta

   Pages 89-114

8. Non-invasive Assessment of Non-alcoholic Fatty Liver Disease: Ultrasound and Transient Elastography

   • Tao Wan, Annalisa Berzigotti

   Pages 115-139

9. MR Based-Imaging Biomarkers in NAFLD/NASH

   • Michael Pavlides

   Pages 141-156

10. Extracellular Vesicles in Non-alcoholic Fatty Liver Disease: Key Players in Disease Pathogenesis and Promising Biomarker Tools

    • Pedro M. Rodrigues, Ainhoa Lapitz, André L. Simão, Maria J. Perugorria, Marco Arrese, Rui E. Castro et al.

    Pages 157-180

11. From Transcriptomic to Metabolomic in the Development of Biomarkers in NAFLD/NASH

    • George V. Dedoussis, Athina I. Amanatidou

    Pages 181-190

12. HCC in Patients with NAFLD/NASH

    • Jose Tadeu Stefano, Fernanda de Mello Malta, Priscila Brizola de Campos, Pedro Fernandes Andrade, Denise Cerqueira Paranaguá-Vezzozo, Flair Jose Carrilho et al.

    Pages 191-203

13. Psychological Biomarker Profile in NAFLD/NASH with Advanced Fibrosis

    • Jesús Funuyet-Salas, Agustín Martín-Rodríguez, Rupert Conrad, María Ángeles Pérez-San-Gregorio

    Pages 205-223

14. Integrative Proposal for the Use of Biomarkers in Clinical Practice Management of NAFLD/NASH

    • Carlos Benítez, Juan Pablo Arab, Francisco Barrera, Jesus M. Banales, Marco Arrese

    Pages 225-236

This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitoring of NASH and NAFLD.  

This is a useful resource for hepatologists, primary care providers with an interest in metabolic disease, diabetologists and endocrinologists in their daily clinical practice.

• liver fibrosis
• elastography
• ultrasound
• liver failure
• biochemical biomarkers
• imaging biomarkers
• non-invasive biomarkers
• hepatology
• Metabolomics

• UCM Digestive Diseases, Virgen del Rocio University Hospital, Sevilla, Spain

  Manuel Romero-Gomez

MANUEL ROMERO GÓMEZ Is Full-Professor of Medicine in the University of Seville, Spain. Digestive Diseases Department at Virgen del Rocío University Hospitals. Institute of Biomedicine of Seville (IBIS). University of Seville. Spain.

Coordinator of the Spanish Registry of NAFLD/NASH (HepaMET) and co-coordinator of the EASL supported European Registry of NAFLD. Principal Investigator of the group for research in the Spanish Network for Research in Digestive and liver diseases (CiberEHD).

 Prof Romero-Gómez received the XI Award Javier Benjumea Puigcerver in investigation, Universidad de Sevilla-Focus Abengoa, 2014. He was awarded with the Medal of The City of Seville in 2016. He has published more than 300 peer-reviewed papers on gastrointestinal and liver diseases. He has protected 10 patents and participated as PI in more than 20 competitive grants for research.

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