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Racing for the Surface

Antimicrobial and Interface Tissue Engineering

  • Provides a basic-science introduction and theory related to osteoinductive studies and tissue engineering

  • Covers key topics in tissue engineering and advances in integration of both antimicrobial and osteoinductive properties

  • Illustrates how current technologies can be used to better understand and develop advanced biomaterials with both osteoinductive and antimicrobial properties that address delayed bone regeneration and infection simultaneously

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xi
  2. Innovative Antimicrobial and Osteoinductive Therapeutics

    1. Front Matter

      Pages 1-1
    2. Advances in Antimicrobial and Osteoinductive Biomaterials

      • Samson Afewerki, Nicole Bassous, Samarah Harb, Carlos Palo-Nieto, Guillermo U. Ruiz-Esparza, Fernanda R. Marciano et al.
      Pages 3-34
    3. Recent Advances in Controlled Release Technologies for the Co-delivery of Antimicrobial and Osteoconductive Therapeutics

      • Chukwuazam Nwasike, Kyle Reeser, Yizhong Liu, Jaspreet Singh Nagi, Erin Purr, Chendong Han et al.
      Pages 35-72
    4. Biofilm-inhibiting and Osseointegration-promoting Orthopedic Implants with Novel Nanocoatings

      • Meng Chen, Hongmin Sun, Hongjiao Ouyang, John E. Jones, Qingsong Yu, Yuanxi Xu et al.
      Pages 73-89
    5. Cationic Antimicrobial Coatings with Osteoinductive Properties

      • Qing Song, Yangyang Pei, Xiaoting Ye, Peng Li, Wei Huang
      Pages 115-128
  3. Interface Tissue Engineering and Advanced Material for Scaffolds

    1. Front Matter

      Pages 223-223
    2. Fracture Healing and Progress Towards Successful Repair

      • William A. Lackington, Keith Thompson
      Pages 225-243
    3. Biofabrication in Tissue Engineering

      • Guangyu Bao
      Pages 289-312
    4. Additive Manufacturing of Bioscaffolds for Bone Regeneration

      • Osama Almayyahi, Irsalan Cockerill, Yufeng Zheng, Donghui Zhu
      Pages 313-332
    5. Anti-biofouling and Antimicrobial Biomaterials for Tissue Engineering

      • Yingnan Zhu, Jia Ke, Lei Zhang
      Pages 333-354
    6. Osteoinductive and Osteoconductive Biomaterials

      • Shreya Agrawal, Rohit Srivastava
      Pages 355-395
    7. Bimetallic Nanoparticles for Biomedical Applications: A Review

      • David Medina-Cruz, Bahram Saleh, Ada Vernet-Crua, Alfonso Nieto-Argüello, Diana Lomelí-Marroquín, Lydia Yerid Vélez-Escamilla et al.
      Pages 397-434
    8. Peptide-mediated Bone Tissue Engineering

      • Abdullah Karadag, Hana’a Iqbal, Hilal Yazici
      Pages 435-476

About this book

This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.


Editors and Affiliations

  • Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, USA

    Bingyun Li

  • AO Research Institute Davos, Davos Platz, Switzerland

    Thomas Fintan Moriarty

  • Department of Chemical Engineering, Northeastern University, Boston, USA

    Thomas Webster

  • Department of Mechanical Engineering, University of Manitoba, Winnipeg, Canada

    Malcolm Xing

About the editors

Bingyun Li is a full Professor with tenure at School of Medicine, West Virginia University. He is a Fellow of the American Institute for Medical and Biological Engineering and an Associate Editor of the Frontiers in Microbiology journal. Professor Li is a member of the Society for Biomaterials (SFB), Orthopedic Research Society (ORS), American Society for Microbiology (ASM), Materials Research Society (MRS), American Chemical Society (ACS), International Chinese Musculoskeletal Research Society (ICMRS), and Chinese Association for Biomaterials (CAB). Professor Li has served as topic chair of Infection and Inflammation of the ORS Program Committee, vice-chair and chair of Orthopedic Biomaterials Special Interest Group of SFB, Chief Editor of ICMRS Newsletter, and inaugural treasurer of CAB. Professor Li’s research focuses on advanced materials, nanomedicine, infection, immunology, and drug delivery. He has published two edited books, 102 articles, 133 abstracts, and 14 provisional/full patents. Professor Li has given 56 invited and keynote talks and has received multiple prestigious awards including the Berton Rahn Prize from AO Foundation, the Pfizer Best Scientific Paper Award from Asia Pacific Orthopedic Association, and the Collaborative Exchange Award from Orthopedic Research Society.

T Fintan Moriarty is group leader of the Musculoskeletal Infection laboratory at the AO Research Institute Davos in Davos Switzerland. The AO Foundation is a medically guided, not-for-profit organization led by an international group of surgeons specialized in the treatment of trauma and disorders of the musculoskeletal system. He is a guest lecturer at the ETH Zurich and Bern University of Applied Sciences lecturing on biomaterial associated infection and musculoskeletal infection. He is scientific editor for the European cells and material (eCM) journal, a highly ranked journal within the biomaterials and orthopedic fields, and organizer of the eCM conference on orthopedic infection. His research focuses on device-related biofilm infections, with a specific focus on fracture related infection. He has previously published a book on biomaterial associated infection and over 70 peer reviewed articles.


Thomas Webster is the Chemical Engineering Department Char and Art Zafiropoulo Endowed Chair at Northeastern University. Prof. Webster has graduated 144 students. His lab group published 9 textbooks, 48 book chapters, 403 articles, and 32 provisional/full patents. Prof. Webster has received numerous honors: 2012, Fellow, American Institute for Medical and Biological Engineering; 2013, Fellow, Biomedical Engineering Society; 2015, Wenzhou 580 Award; 2015, Zheijang 1000 Talent Program; 2016, IMRC Chinese Academy of Science Lee-Hsun Lecture Award; 2016, Fellow, Biomaterials Science and Engineering; and 2016, Acta Biomaterialia Silver Award. He also frequently appears on the BBC, NBC, ABC, Fox, National Geographic, Discovery Channel and many other news outlets talking about science.



Malcolm Xing is a professor of University of Manitoba. His research focuses on smart biomaterials for tissue engineering, nanomedicine, wearable biosensor, implantable bio-robot and 3D/4D bioprinting. He has obtained awards such as National Science & Engineering Research Council Discovery Accelerator Supplement Award, Canada Foundation for Innovation - Innovation Fund, CBA-BA Young Investigator Award in ACS 2017 and Dr. J.A. Moorhouse Fellowship of the Diabetes Foundation of Manitoba.  Dr. Xing was the invited speaker of 2019 Society for Biomaterials Annual Conference and Keynote speaker of 2019 Canada Biomaterials Society (CBS) Conference, and the conference chair of CBS2017. His research has been covered in media including Time, Fortune, Discovery, Science, ACS headline news, RSC, CTV, CBC, etc.

Bibliographic Information

  • Book Title: Racing for the Surface

  • Book Subtitle: Antimicrobial and Interface Tissue Engineering

  • Editors: Bingyun Li, Thomas Fintan Moriarty, Thomas Webster, Malcolm Xing

  • DOI: https://doi.org/10.1007/978-3-030-34471-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-34470-2Published: 29 February 2020

  • Softcover ISBN: 978-3-030-34473-3Published: 28 February 2021

  • eBook ISBN: 978-3-030-34471-9Published: 28 February 2020

  • Edition Number: 1

  • Number of Pages: XI, 809

  • Number of Illustrations: 26 b/w illustrations, 126 illustrations in colour

  • Topics: Biomedical Engineering/Biotechnology, Biomaterials, Biomedical Engineering and Bioengineering

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access