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Advanced Concepts in Human Immunology: Prospects for Disease Control

  • Book
  • © 2020

Overview

Editors:
  1. Pooja Jain

    1. Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, USA

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  2. Lishomwa C. Ndhlovu

    1. Department of Medicine-Division of Infectious Diseases, Weill Cornell Medicine, New York, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Synthesizes current research to provide a thorough understanding of the behavior of the human immune system

  • Includes unique coverage of immunoproteomics for immunotherapy, and clinical perspectives on Polycystic Ovarian Syndrome

  • Key resource for clinicians as well as researchers in academia and industry

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Human Acute and Chronic Viruses: Host-Pathogen Interactions and Therapeutics

    • Matilde Hoffman, DeGaulle I. Chigbu, Brenndan L. Crumley, Ravi Sharma, Sergey Pustylnikov, Thomas Crilley et al.
    Pages 1-120

  3. Applications of Cutting-Edge Immunoproteomics Technology in Human Immunotherapy

    • Joseph Comber, Ramila Philip
    Pages 121-159

  4. Microbiome and Cellular Players in Type 1 Diabetes: From Pathogenesis to Protection

    • Darshan Badal, Mahinder Paul, Neenu Jacob, Naresh Sachdeva
    Pages 161-227

  5. Immune Mechanisms, Pathology, and Management of Allergic Ocular Diseases

    • DeGaulle I. Chigbu, Pooja Jain, Zafar K. Khan
    Pages 229-277

  6. Dendritic Cell-Regulated T Cell Immunity and Tolerance against Acute Myeloid Leukemia

    • Yuanyuan Tian, Hongshuang Yu, Shaoyan Hu, Yi Zhang
    Pages 279-296

  7. Perspectives on the Role of T Cell Negative Immune Checkpoint Receptors in Health and Disease

    • Tsuyoshi Fujita, Danielle M. Clements, Thomas A. Premeaux, Lishomwa C. Ndhlovu
    Pages 297-318

  8. Chimeric Antigen Receptor T Cells: Clinical Applications, Advances and Challenges

    • Margaret H. O’Connor, Kiran Madugula, Melody Smith
    Pages 319-333

  9. Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases

    • Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman
    Pages 335-370

  10. Polycystic Ovary Syndrome: An Overview of a Complex, Heterogenous Genetic Condition

    • Shailaja Nair, Yolaine Nkamga, Bryson Hoover-Hankerson
    Pages 371-386

  11. Back Matter

    Pages 387-403
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Keywords

About this book

This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.

Editors and Affiliations

  • Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, USA

    Pooja Jain

  • Department of Medicine-Division of Infectious Diseases, Weill Cornell Medicine, New York, USA

    Lishomwa C. Ndhlovu

About the editors

Pooja Jain, PhD, is a Professor in the Department of Microbiology and Immunology as well as Neurobiology and Anatomy at the Drexel University College of Medicine located in Philadelphia, USA. Her research focuses on the host-pathogen interactions underlying Adult T-Cell Leukemia Lymphoma (ATLL) induced by Human T-cell leukemia virus type 1 (HTLV-1). In addition, her Dr. Jain’s laboratory is engaged in testing novel targets for myeloid cell-immunotherapy against neuroinflammtory diseases such as Multiple Sclerosis and HAM/TSP (HTLV-associated myelopathy/tropical spastic paraparesis).

Lishomwa C. Ndhlovu, PhD, is a Professor at the John A. Burns School of Medicine, University of Hawaii. His research focuses on understanding the impact of HIV on the immune system as well as how this host-HIV interaction will inform potential clinical applications in balancing strategies to slow or eliminate HIV infection and optimize quality of life outcomes. Dr. Ndhlovu’s laboratory is also investigating the role of negative checkpoint regulators (NCR) in HIV, as potential immunotherapy that reverse immune perturbation in HIV.

Bibliographic Information

  • Book Title: Advanced Concepts in Human Immunology: Prospects for Disease Control

  • Editors: Pooja Jain, Lishomwa C. Ndhlovu

  • DOI: https://doi.org/10.1007/978-3-030-33946-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-33945-6Published: 13 August 2020

  • Softcover ISBN: 978-3-030-33948-7Published: 14 August 2021

  • eBook ISBN: 978-3-030-33946-3Published: 11 August 2020

  • Edition Number: 1

  • Number of Pages: XVIII, 403

  • Number of Illustrations: 11 b/w illustrations, 5 illustrations in colour

  • Topics: Immunology, Vaccine, Infectious Diseases, Cancer Research

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