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Handbook of Experimental Pharmacology

Lipid Signaling in Human Diseases

Editors: Gomez-Cambronero, Julian, Frohman, Michael A. (Eds.)

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  • Reviews the current status of the field of lipid signaling focused on translational significance with the prospect to be clinically relevant for human disease
  • The book combines both basic principles and applied agents with clinical significance for lipid cell signaling, phospholipases and lipid kinases, lipid metabolism and trafficking, and bioactive lipids
  • Drug development and novel application ideas are incorporated where possible
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  • ISBN 978-3-030-33668-4
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About this book

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease.

Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.

 

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma

    Pages 3-17

    Maceyka, Michael (et al.)

  • Exploring the Therapeutic Landscape of Sphingomyelinases

    Pages 19-47

    Shanbhogue, Prajna (et al.)

  • Sphingosine Kinases as Druggable Targets

    Pages 49-76

    Pyne, Susan (et al.)

  • Prospects for PLD Inhibition in Cancer and Thrombotic Disease

    Pages 79-88

    Salazar, Christian (et al.)

  • Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer

    Pages 89-113

    Gomez-Cambronero, Julian (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-3-030-33668-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Lipid Signaling in Human Diseases
Editors
  • Julian Gomez-Cambronero
  • Michael A. Frohman
Series Title
Handbook of Experimental Pharmacology
Series Volume
259
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-33668-4
DOI
10.1007/978-3-030-33668-4
Hardcover ISBN
978-3-030-33667-7
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XIV, 336
Number of Illustrations
20 b/w illustrations, 30 illustrations in colour
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