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Good Research Practice in Non-Clinical Pharmacology and Biomedicine

  • Book
  • Open Access
  • © 2020

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Overview

Editors:
  1. Anton Bespalov

    1. Partnership for Assessment & Accreditation of Scientific Practice, Heidelberg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Martin C. Michel

    1. Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Thomas Steckler

    1. Janssen Pharmaceutica N.V., Beerse, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  • First comprehensive book on factors associated with high risk for poor reproducibility of non-clinical findings
  • Inclusion of aspects of study design, data analysis and data reporting
  • Broad applicability to in vitro and in vivo research across all therapeutic areas

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 257)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-x
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  2. Quality in Non-GxP Research Environment

    • Sandrine Bongiovanni, Robert Purdue, Oleg Kornienko, René Bernard
    Pages 1-17Open Access
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  3. Guidelines and Initiatives for Good Research Practice

    • Patricia Kabitzke, Kristin M. Cheng, Bruce Altevogt
    Pages 19-34Open Access
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  4. Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices

    • Isabel A. Lefevre, Rita J. Balice-Gordon
    Pages 35-54Open Access
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  5. General Principles of Preclinical Study Design

    • Wenlong Huang, Nathalie Percie du Sert, Jan Vollert, Andrew S. C. Rice
    Pages 55-69Open Access
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  6. Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research

    • Ulrich Dirnagl
    Pages 71-79Open Access
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  7. Blinding and Randomization

    • Anton Bespalov, Karsten Wicke, Vincent Castagné
    Pages 81-100Open Access
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  8. Out of Control? Managing Baseline Variability in Experimental Studies with Control Groups

    • Paul Moser
    Pages 101-117Open Access
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  9. Quality of Research Tools

    • Dario Doller, Paul Wes
    Pages 119-145Open Access
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  10. Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies

    • Stacey J. Sukoff Rizzo, Stephanie McTighe, David L. McKinzie
    Pages 147-162Open Access
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  11. Building Robustness into Translational Research

    • Betül R. Erdogan, Martin C. Michel
    Pages 163-175Open Access
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  12. Minimum Information and Quality Standards for Conducting, Reporting, and Organizing In Vitro Research

    • Christoph H. Emmerich, Christopher M. Harris
    Pages 177-196Open Access
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  13. Minimum Information in In Vivo Research

    • Patrizia Voehringer, Janet R. Nicholson
    Pages 197-222Open Access
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  14. A Reckless Guide to P-values

    • Michael J. Lew
    Pages 223-256Open Access
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  15. Electronic Lab Notebooks and Experimental Design Assistants

    • Björn Gerlach, Christopher Untucht, Alfred Stefan
    Pages 257-275Open Access
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  16. Data Storage

    • Christopher Frederick Isambard Blumzon, Adrian-Tudor Pănescu
    Pages 277-297Open Access
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  17. Design of Meta-Analysis Studies

    • Malcolm R. Macleod, Ezgi Tanriver-Ayder, Kaitlyn Hair, Emily Sena
    Pages 299-317Open Access
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  18. Publishers’ Responsibilities in Promoting Data Quality and Reproducibility

    • Iain Hrynaszkiewicz
    Pages 319-348Open Access
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  19. Quality Governance in Biomedical Research

    • Anja Gilis
    Pages 349-365Open Access
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  20. Good Research Practice: Lessons from Animal Care and Use

    • Javier Guillén, Thomas Steckler
    Pages 367-382Open Access
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Keywords

About this book

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Editors and Affiliations

  • Partnership for Assessment & Accreditation of Scientific Practice, Heidelberg, Germany

    Anton Bespalov

  • Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany

    Martin C. Michel

  • Janssen Pharmaceutica N.V., Beerse, Belgium

    Thomas Steckler

Bibliographic Information

  • Book Title: Good Research Practice in Non-Clinical Pharmacology and Biomedicine

  • Editors: Anton Bespalov, Martin C. Michel, Thomas Steckler

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-030-33656-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2020

  • Hardcover ISBN: 978-3-030-33655-4Published: 21 February 2020

  • Softcover ISBN: 978-3-030-33658-5Published: 11 September 2020

  • eBook ISBN: 978-3-030-33656-1Published: 20 February 2020

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: X, 423

  • Number of Illustrations: 13 b/w illustrations, 21 illustrations in colour

  • Topics: Pharmacology/Toxicology, Neurosciences, Cardiology, Oncology

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