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Topics in Heterocyclic Chemistry

Carbohydrate-spiro-heterocycles

Editors: SOMSÁK, László (Ed.)

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  • Provides an overview of recent developments in spirocyclization techniques adapted to carbohydrates
  • Presents recent advances in the utility of sugar derived spiro-heterocycles
  • Multi-authored volume with contributions from experts in the field
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-030-31942-7
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-030-31941-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.


About the authors

László Somsák is a full Professor and Head of the Department of Organic Chemistry at the University of Debrecen, Hungary. He serves as an editorial board member for Carbohydrate Research, and as guest editor for special issues of Carbohydrate Research, Mini-Reviews in Medicinal Chemistry, Molecules. His research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivatives; development of synthetic methodology involving radicals and carbenes; synthesis of glycosidase and glycogen phosphorylase inhibitors as potential antidiabetics, study of their structure-activity relationships; synthesis of glycomimetics and glycopeptidomimetics.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Anomeric Spiro-Annulated Glycopyranosides: An Overview of Synthetic Methodologies and Biological Applications

    Pages 1-25

    Pommier, Maxime (et al.)

  • Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes

    Pages 27-49

    Pellegrini-Moïse, Nadia (et al.)

  • Carbohydrate Spiro-heterocycles via Radical Chemistry

    Pages 51-104

    Martín, Angeles (et al.)

  • Carbohydrate-Derived Spiroketals and Spirocyclic Lactones

    Pages 105-136

    Sridhar, Perali Ramu

  • Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars

    Pages 137-169

    Josse, Solen (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-030-31942-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-030-31941-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Carbohydrate-spiro-heterocycles
Editors
  • László SOMSÁK
Series Title
Topics in Heterocyclic Chemistry
Series Volume
57
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-31942-7
DOI
10.1007/978-3-030-31942-7
Hardcover ISBN
978-3-030-31941-0
Series ISSN
1861-9282
Edition Number
1
Number of Pages
VII, 295
Number of Illustrations
1 b/w illustrations
Topics