- Provides an overview of recent developments in spirocyclization techniques adapted to carbohydrates
- Presents recent advances in the utility of sugar derived spiro-heterocycles
- Multi-authored volume with contributions from experts in the field
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- About this book
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This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.
- About the authors
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László Somsák is a full Professor and Head of the Department of Organic Chemistry at the University of Debrecen, Hungary. He serves as an editorial board member for Carbohydrate Research, and as guest editor for special issues of Carbohydrate Research, Mini-Reviews in Medicinal Chemistry, Molecules. His research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivatives; development of synthetic methodology involving radicals and carbenes; synthesis of glycosidase and glycogen phosphorylase inhibitors as potential antidiabetics, study of their structure-activity relationships; synthesis of glycomimetics and glycopeptidomimetics.
- Table of contents (8 chapters)
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Anomeric Spiro-Annulated Glycopyranosides: An Overview of Synthetic Methodologies and Biological Applications
Pages 1-25
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Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes
Pages 27-49
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Carbohydrate Spiro-heterocycles via Radical Chemistry
Pages 51-104
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Carbohydrate-Derived Spiroketals and Spirocyclic Lactones
Pages 105-136
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Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars
Pages 137-169
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Table of contents (8 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Carbohydrate-spiro-heterocycles
- Editors
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- László SOMSÁK
- Series Title
- Topics in Heterocyclic Chemistry
- Series Volume
- 57
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-31942-7
- DOI
- 10.1007/978-3-030-31942-7
- Hardcover ISBN
- 978-3-030-31941-0
- Softcover ISBN
- 978-3-030-31944-1
- Series ISSN
- 1861-9282
- Edition Number
- 1
- Number of Pages
- VII, 295
- Number of Illustrations
- 1 b/w illustrations
- Topics
