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The Biology of mRNA: Structure and Function

  • Book
  • © 2019

Overview

Editors:
  1. Marlene Oeffinger

    1. Systems biology (IRCM), Biochemistry and Molecular Medicine (UdeM), Experimental Medicine (McGill), Institut de recherches cliniques de Montréal (IRCM), Université de Montréal, McGill University, Montreal, Canada

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  2. Daniel Zenklusen

    1. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • mRNA centric view on gene regulation
  • depicts the most recent findings in mRNA biology in a comprehensive manner
  • features new aspects of mRNA disease relations and mRNA structure

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1203)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export

    • Wolfgang Wende, Peter Friedhoff, Katja Sträßer
    Pages 1-31

  3. It’s Not the Destination, It’s the Journey: Heterogeneity in mRNA Export Mechanisms

    • Daniel D. Scott, L. Carolina Aguilar, Mathew Kramar, Marlene Oeffinger
    Pages 33-81

  4. View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover

    • Marius Wegener, Michaela Müller-McNicoll
    Pages 83-112

  5. The Nuclear RNA Exosome and Its Cofactors

    • Manfred Schmid, Torben Heick Jensen
    Pages 113-132

  6. 3′-UTRs and the Control of Protein Expression in Space and Time

    • Traude H. Beilharz, Michael M. See, Peter R. Boag
    Pages 133-148

  7. Communication Is Key: 5′–3′ Interactions that Regulate mRNA Translation and Turnover

    • Hana Fakim, Marc R. Fabian
    Pages 149-164

  8. Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization

    • Louis Philip Benoit Bouvrette, Mathieu Blanchette, Eric Lécuyer
    Pages 165-194

  9. RNA Granules and Their Role in Neurodegenerative Diseases

    • Hadjara Sidibé, Christine Vande Velde
    Pages 195-245

  10. Lessons from (pre-)mRNA Imaging

    • Srivathsan Adivarahan, Daniel Zenklusen
    Pages 247-284

  11. Diverging RNPs: Toward Understanding lncRNA-Protein Interactions and Functions

    • Martin Sauvageau
    Pages 285-312
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Keywords

About this book

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. 
This book shows how new technologies have led to a better understanding of these processes and their connected diseases.
The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.




Editors and Affiliations

  • Systems biology (IRCM), Biochemistry and Molecular Medicine (UdeM), Experimental Medicine (McGill), Institut de recherches cliniques de Montréal (IRCM), Université de Montréal, McGill University, Montreal, Canada

    Marlene Oeffinger

  • Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada

    Daniel Zenklusen

About the editors

Marlene Oeffinger is Associate Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada, and Adjunct Professor in the Division of Experimental Medicine at McGill University. Her laboratory uses Proteomic, RNomic and biochemical approaches to study the regulation, dynamics and functional niches of RNA maturation pathways and their implications in neurodegenerative diseases.

Daniel Zenklusen is an Associate Professor at the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada. His laboratory uses single molecule and super-resolution microscopy approaches to study different aspects of gene expression in single cells, including RNA transport and localization, lncRNAs function and mRNP organization.

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