Therapy Response Imaging in Oncology

1. Front Matter

   Pages i-viii

   PDF

2. Imaging as a “Common Language” for Treatment Response Evaluations in Oncology

   1. Front Matter

      Pages 1-1

      PDF

   2. Conventional Tumor Response Criteria and Limitations

      • Mizuki Nishino

      Pages 3-14

   3. Response Evaluations for Precision Cancer Therapy and Immunotherapy

      • Mizuki Nishino

      Pages 15-27

3. Practical Pitfalls in Therapy Response Imaging in Cancer Patients

   1. Front Matter

      Pages 29-29

      PDF

   2. Drug Toxicity, Approach to Cancer as a Systemic Disease, and Imaging Modality-Specific Considerations

      • Hyesun Park, Mizuki Nishino

      Pages 31-43

4. Part III

   1. Front Matter

      Pages 45-45

      PDF

   2. Therapy Response Imaging in Central Nervous System (CNS) Malignancy

      • Peter Abraham, Jason Handwerker

      Pages 47-63

   3. Therapy Response Imaging in Breast Cancer

      • Masako Kataoka

      Pages 65-78

   4. Therapy Response Imaging in Thoracic Malignancy

      • Mizuki Nishino

      Pages 79-97

   5. Therapy Response Imaging in Gastrointestinal Malignancy

      • Satomi Kawamoto

      Pages 99-115

   6. Therapy Response Imaging in Hepatobiliary and Pancreatic Malignancies

      • Sanaz Ameli, Mohammadreza Shaghaghi, Ihab R. Kamel, Atif Zaheer

      Pages 117-137

   7. Therapy Response Imaging in Genitourinary Malignancies

      • Katherine M. Krajewski

      Pages 139-157

   8. Therapy Response Imaging in Gynecologic Malignancies

      • Aki Kido

      Pages 159-176

   9. Therapy Response Imaging in Lymphoma and Hematologic Malignancies

      • Hina Shah, Heather Jacene

      Pages 177-200

   10. Therapy Response Imaging in Sarcoma and Musculoskeletal Malignancies

       • Sree Harsha Tirumani

       Pages 201-217

5. Emerging Approaches and Future Directions

   1. Front Matter

      Pages 219-219

      PDF

   2. Radiomics and Imaging Genomics for Evaluation of Tumor Response

      • Geewon Lee, So Hyeon Bak, Ho Yun Lee, Joon Young Choi, Hyunjin Park

      Pages 221-238

   3. Evolution of Clinical Trial Imaging and Co-clinical Imaging

      • Amy Junghyun Lee, Chong Hyun Suh, Kyung Won Kim

      Pages 239-253

   4. Molecular and Functional Imaging in Oncology Therapy Response

      • Katherine A. Zukotynski, Phillip H. Kuo, Chun K. Kim, Rathan M. Subramaniam

      Pages 255-272

This book is a detailed guide to therapy response imaging in cancer patients that fully takes into account the revolutionary progress and paradigm shift in treatment approaches for advanced disease. The opening chapters describe the role of imaging as a “common language” for tumor response evaluation in oncology and address challenges and strategies in the era of precision cancer therapy and cancer immunotherapy. Practical pitfalls are discussed, with emphasis on the importance of approaching cancer as a systemic disease and the need for increased awareness of drug toxicity due to novel therapies. Therapy response imaging in a wide range of cancer types is then comprehensively described and illustrated, using a disease-specific approach. A concluding section focuses on emerging approaches and future directions, including radiomics/radiogenomics, co-clinical imaging, and molecular and functional imaging. Therapy Response Imaging in Oncology will be of high value for radiologists,nuclear medicine physicians, and oncologists. It will also be of interest to cancer care providers and oncology trial investigators.

• Tumor response evaluation in oncology
• Oncologic imaging
• Tumor response assessment
• Precision medicine
• Cancer Immunotherapy
• Positron emission tomography
• Precision cancer therapy and immunotherapy
• Radiogenomics for tumor response evaluations
• Co-clinical imaging in oncology
• Radiomics for tumor response evaluations
• Diagnostic Radiology

• Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

  Mizuki Nishino

Mizuki Nishino is a diagnostic radiologist specialized in oncologic imaging, with a particular focus on therapy response imaging in the setting of precision cancer therapy and cancer immunotherapy. Dr. Nishino is a fellowship-trained thoracic radiologist. Her research has focused on therapy response imaging in lung cancer treated with molecular targeting therapy, contributing to the identification of objective imaging markers to predict treatment benefit and clinical outcome. Dr. Nishino has also applied her expertise to therapy response imaging in cancer immunotherapy and has published a series of fundamental studies to refine strategies for immune-related response evaluation. In addition she has made contributions to imaging-based characterization of drug toxicities in cancer patients treated with precision therapy and immunotherapy. Dr. Nishino published the first report of clinical and imaging characteristics of immune checkpoint inhibitor-related pneumonitis, defined the spectrumof radiographic manifestations of the entity, and continues to work on the topic to develop strategies for early detection and accurate diagnosis.

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