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Current Topics in Microbiology and Immunology

Fc Mediated Activity of Antibodies

Structural and Functional Diversity

Editors: Ravetch, Jeffrey V., Nimmerjahn, Falk (Eds.)

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  • Examines the structural diversity of the Fc domain for IgG and IgE
  • Explores the role of Fc receptors in the context of infectious, autoimmune, and neoplastic disorders
  • Provides comprehensive information on Fc receptor pathways as an essential part of the immune response
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eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-030-31053-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-31052-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

About the authors

Jeffrey V. Ravetch

Theresa and Eugene M. Lang Professor

Department Leonard Wagner Laboratory of Molecular Genetics and Immunology

Rockefeller University

1230 York Avenue, Box 98

New York, NY 10021, USA

ravetch@mail.rockefeller.edu


Falk Nimmerjahn

Professor for Immunology and Genetics

Chairman of the Institute of Genetics

Head of the Department of Biology

Department of Biology

University of Erlangen-Nuernberg

Erwin-Rommelstr. 3

91058 Erlangen, Germany

falk.nimmerjahn@fau.de


Table of contents (7 chapters)

Table of contents (7 chapters)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-030-31053-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-31052-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Fc Mediated Activity of Antibodies
Book Subtitle
Structural and Functional Diversity
Editors
  • Jeffrey V. Ravetch
  • Falk Nimmerjahn
Series Title
Current Topics in Microbiology and Immunology
Series Volume
423
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-31053-0
DOI
10.1007/978-3-030-31053-0
Hardcover ISBN
978-3-030-31052-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 150
Number of Illustrations
2 b/w illustrations, 12 illustrations in colour
Topics