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Current Topics in Microbiology and Immunology

Fungal Physiology and Immunopathogenesis

Editors: Rodrigues, Marcio L. (Ed.)

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  • Shares new insights into how fungal pathogens damage host cells
  • Covers key aspects of fungal pathogenesis and the mechanisms behind fungal virulence
  • Sheds new light on the high costs of, and elevated levels of toxicity in, antifungal therapy
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-30237-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-30236-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume offers an overview of the various aspects involved in the ability of fungi to damage host cells, and discusses cutting-edge approaches to the study of fungal pathogenesis. The first chapter illustrate the key roles of glycans and pigments, the most abundant surface components in fungal cells, in their interactions with host cells. The connections between cellular physiology and fungal pathogenesis are then discussed in the following chapters. Physiology-related processes affecting pathogenesis include fungal secretion, morphological transitions, and response to light.

In turn, the book illustrates mechanisms of damage to host cells using the Histoplasma capsulatum model of infection, and reviews the use of transcriptomic approaches to understand the mechanisms of interaction between fungal cells and host tissues. After a discussion of the immunological mechanisms underlying host susceptibility to fungal infections, the book’s closing contribution reviews the mechanisms of interaction between fungi and other microbes, and the impact of this association on fungal pathogenesis. Given its scope, the book will appeal to scientists in the fields of mycology, microbiology, infectious diseases, biology and medicine.

About the authors

Marcio Rodrigues is a senior investigator in the Carlos Chagas Institute (Oswaldo Cruz Foundation, Fiocruz; Brazil). His laboratory is mainly interested in the mechanisms by which fungal cells export biologically active molecules to the extracellular space. In this context, the laboratory has been investigating the role of extracellular vesicles in fungal physiology and pathogenesis for the last decade, mainly using the Cryptococcus model of secretion. The group is especially interested in how lipids and glycans participate in secretory processes that are essential for fungi, aiming to connect basic cell biology mechanisms with the identification of cellular pathways that could be targeted by novel antifungal agents. 

Table of contents (10 chapters)

Table of contents (10 chapters)
  • The Role of Melanin in Fungal Pathogenesis for Animal Hosts

    Pages 1-30

    Smith, Daniel F. Q. (et al.)

  • The Overlooked Glycan Components of the Cryptococcus Capsule

    Pages 31-43

    Fonseca, Fernanda L. (et al.)

  • Extracellular Vesicles in Fungi: Composition and Functions

    Pages 45-59

    Toledo Martins, Sharon (et al.)

  • From Genes to Networks: The Regulatory Circuitry Controlling Candida albicans Morphogenesis

    Pages 61-99

    Basso, Virginia (et al.)

  • Cryptococcal Titan Cells: When Yeast Cells Are All Grown up

    Pages 101-120

    García-Rodas, Rocío (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-30237-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-30236-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Fungal Physiology and Immunopathogenesis
Editors
  • Marcio L. Rodrigues
Series Title
Current Topics in Microbiology and Immunology
Series Volume
422
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-30237-5
DOI
10.1007/978-3-030-30237-5
Hardcover ISBN
978-3-030-30236-8
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VIII, 301
Number of Illustrations
4 b/w illustrations, 19 illustrations in colour
Topics