Get 40% off of select print and eBooks in Engineering & Materials Science!

Springer Theses

Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica

Authors: Bräuning, Bastian

Free Preview
  • Nominated as an outstanding Ph.D. thesis by the Technische Universitat Munchen, Garching, Germany
  • Serves as a comprehensive case study of a difficult target protein
  • Focuses on cutting-edge methodology currently in high demand
see more benefits

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-030-29439-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-29438-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts. 

About the authors

Bastian Bräuning completed his undergraduate and postgraduate education at the LMU Munich and the Weizmann Institute of Science, Israel. He subsequently pursued doctoral training with Prof. Michael Groll at the TUM Munich, where he mastered biochemical and structural techniques for the analysis of membrane protein complexes. Currently, he is a postdoctoral fellow in Prof. Brenda Schulman’s group at the Max Planck Institute of Biochemistry, where his focus continues to be on challenging membrane protein targets and their regulation. 

Table of contents (5 chapters)

Table of contents (5 chapters)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-030-29439-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-29438-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica
Authors
Series Title
Springer Theses
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-29439-7
DOI
10.1007/978-3-030-29439-7
Hardcover ISBN
978-3-030-29438-0
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXXI, 86
Topics