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Boston Studies in the Philosophy and History of Science

Uncertainty in Pharmacology

Epistemology, Methods, and Decisions

Editors: LaCaze, Adam, Osimani, Barbara (Eds.)

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  • Proposes various incentives to improve the pharmaceutical landscape
  • Analyses and solves methodological problems by drawing on epistemological tools
  • Refines and improves current approaches to evidence evaluation, drug decision making, and pharmaceutical/health policies
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  • ISBN 978-3-030-29179-2
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About this book

This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.

About the authors

Prof. Barbara Osimani is Associate Professor of Logic and Philosophy of Science at the Polytechnic University of the Marche and is currently heading an ERC project, which also runs at the Munich Center for Mathematical Philosophy, LMU: "Philosophy of Pharmacology: Safety, Statistical Standards, and Evidence Amalgamation". 

She is interested in scientific inference in research contexts characterised by strategic behaviour and she is developing a "Formal Epistemology of Medicine" in order to analyse issues arising in medical research, with a special focus on the complex interaction of methodological, social and regulatory as well as ethical dimensions in medicine. She worked on the precautionary principle, evidence hierarchies, causal assessment of pharmaceutical harm, and statistical inference. Her recent papers analyse issues around philosophy of evidence (reliability, bias, reproducibility, coherence) from a Bayesian perspective. Within her ERC project: "Philosophy of Pharmacology: Safety, Statistical Standards, and Evidence Amalgamation" she developed a Bayesian framework for the integration of heterogenous items of evidence for the purpose of causal assessment of drug-induced harm ("E-Synthesis")

Dr. La Caze is a lecturer at the School of Pharmacy, University of Queensland. He completed his PhD in the philosophy of science at The University of Sydney. His research focusses on philosophy of science, philosophy of medicine and ethics. He is particularly interested in exploring philosophical approaches to challenges that arise in interpreting and applying biomedical research.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Defining Aspects of Mechanisms: Evidence-Based Mechanism (Evidence for a Mechanism), Mechanism-Based Evidence (Evidence from a Mechanism), and Mechanistic Reasoning

    Pages 3-38

    Aronson, Jeffrey K.

  • Causal Insights from Failure: Post-marketing Risk Assessment of Drugs as a Way to Uncover Causal Mechanisms

    Pages 39-57

    Rocca, Elena (et al.)

  • Extrapolating from Model Organisms in Pharmacology

    Pages 59-78

    Parkkinen, Veli-Pekka (et al.)

  • Mechanistic vs Statistical Extrapolation in Preclinical Research in Psychiatry: Challenging the Received View

    Pages 79-100

    Belzung, Catherine (et al.)

  • Analogy-Based Inference Patterns in Pharmacological Research

    Pages 101-133

    Poellinger, Roland

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-030-29179-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
  • ISBN 978-3-030-29178-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Uncertainty in Pharmacology
Book Subtitle
Epistemology, Methods, and Decisions
Editors
  • Adam LaCaze
  • Barbara Osimani
Series Title
Boston Studies in the Philosophy and History of Science
Series Volume
338
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-29179-2
DOI
10.1007/978-3-030-29179-2
Hardcover ISBN
978-3-030-29178-5
Series ISSN
0068-0346
Edition Number
1
Number of Pages
XIII, 470
Number of Illustrations
48 b/w illustrations
Topics