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Endometrial Gene Expression

An Emerging Paradigm for Reproductive Disorders

  • Book
  • © 2020

Overview

  • Presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders

  • Discusses gene expression in cases of repeated implant failure, immune profiling, recurrent pregnancy loss, infection, uterine fibroids, endometriosis and other reproductive and gynecological malignancies

  • Ideal for for reproductive endocrinologists, gynecologists, fetal medicine specialists, and all clinicians treating female infertility

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Table of contents (13 chapters)

Keywords

About this book

The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. 


This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses,  infertility and multiple implantation failures are presented with currently available endometrial gene analysis.

Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.  

Editors and Affiliations

  • Reproductive Medicine and Immunology Clinical Sciences, Obstetrics and Gynecology, Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, USA

    Joanne Kwak-Kim

About the editor

Joanne Kwak-Kim, MD, MPH, Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.

 

Bibliographic Information

  • Book Title: Endometrial Gene Expression

  • Book Subtitle: An Emerging Paradigm for Reproductive Disorders

  • Editors: Joanne Kwak-Kim

  • DOI: https://doi.org/10.1007/978-3-030-28584-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-28583-8Published: 21 November 2019

  • Softcover ISBN: 978-3-030-28586-9Published: 21 November 2020

  • eBook ISBN: 978-3-030-28584-5Published: 08 November 2019

  • Edition Number: 1

  • Number of Pages: XIII, 220

  • Number of Illustrations: 15 illustrations in colour

  • Topics: Reproductive Medicine, Gynecology, Gene Expression

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