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Advances in Experimental Medicine and Biology

Pluripotent Stem Cells in Eye Disease Therapy

Editors: Bharti, Kapil (Ed.)

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  • Discusses both novel clinical applications and future directions
  • Presents an international perspective from worldwide experts in the field
  • Comprehensive coverage includes both basic science and applications of pluripotent stem cells to study eye disease
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eBook $119.00
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  • ISBN 978-3-030-28471-8
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Hardcover $159.99
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  • ISBN 978-3-030-28470-1
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About this book

This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. 

Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases. 

About the authors

Dr. Kapil Bharti holds a bachelor’s degree in Biophysics from the Panjab University, Chandigarh, India, a master’s degree in biotechnology from the M.S. Rao University, Baroda, India. He obtained his Ph.D. from J.W. Goethe University, Frankfurt, Germany, graduating summa cum laude. His Ph.D. work involved research in the areas of heat stress, chaperones, and epigenetics.  He did his postdoc at the National Institutes of Health, where he published numerous papers in the areas of transcription regulation, pigment cell biology, and developmental biology of the eye. After his postdoc, he joined the National Eye Institute as their first Earl Stadtman Tenure-Track Investigator. His lab was recently awarded two prestigious grants: 1) the only Intramural Common Fund grant to develop a phase I Investigational New Drug (IND) for Autologous induced pluripotent stem cell derived retinal pigment epithelium tissue; and 2) a DoD grant to develop a 3D-retina tissue to model retinal diseases in vitro. His current work as a Senior Investigator and the head of the Unit on Ocular and Stem Cell Translational Research involves understanding mechanism of retinal degenerative diseases using induced pluripotent stem cell technology, and developing cell-based and drug-based therapies for such diseases.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective

    Pages 1-31

    Dalvi, Sonal (et al.)

  • Utility of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for an In Vitro Model of Proliferative Vitreoretinopathy

    Pages 33-53

    Greene, Whitney A. (et al.)

  • Developing Cell-Based Therapies for RPE-Associated Degenerative Eye Diseases

    Pages 55-97

    Ben M’Barek, Karim (et al.)

  • Immunological Considerations for Retinal Stem Cell Therapy

    Pages 99-119

    Kramer, Joshua (et al.)

  • Advances in the Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells

    Pages 121-140

    Ohlemacher, Sarah K. (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-030-28471-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-28470-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pluripotent Stem Cells in Eye Disease Therapy
Editors
  • Kapil Bharti
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1186
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-28471-8
DOI
10.1007/978-3-030-28471-8
Hardcover ISBN
978-3-030-28470-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 201
Number of Illustrations
1 b/w illustrations, 19 illustrations in colour
Topics