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  • © 2020

Retinal Pigment Epithelium in Health and Disease

  • Written by experts at the forefront of Retinal Pigment Epithelium (RPE) research
  • Contain contemporary state-of-the-art knowledge, as well relevant new findings
  • Provides an up-to-date compendium for RPE and includes experimental models specific for RPE

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xi
  2. Physiological RPE Function

    1. Front Matter

      Pages 1-1
    2. RPE Histopathology and Morphometry

      • Eszter Szalai, John M. Nickerson, Hans E. Grossniklaus
      Pages 3-17
    3. RPE Polarity and Barrier Function

      • Lawrence J. Rizzolo
      Pages 19-45
    4. RPE Phagocytosis

      • Claudia Müller, Silvia C. Finnemann
      Pages 47-63
    5. Ion Channels of the Retinal Pigment Epithelium

      • Nadine Reichhart, Olaf Strauß
      Pages 65-84
    6. RPE and the Vascular Endothelial Growth Factor

      • Alexa Karina Klettner
      Pages 85-99
    7. The RPE Cell and the Immune System

      • Barbara Detrick, John J. Hooks
      Pages 101-114
  3. The RPE in Disease

    1. Front Matter

      Pages 115-115
    2. The RPE in Myopia Development

      • Yan Zhang, Christine F. Wildsoet
      Pages 117-138
    3. Retinal Pigment Epithelium in Proliferative Disorders

      • Willem A. Dik, Jeroen Bastiaans, Jan C. van Meurs
      Pages 139-160
    4. Retinal Pigment Epithelium in Age-Related Macular Degeneration

      • Kai Kaarniranta, Antero Salminen, Anu Kauppinen
      Pages 161-171
    5. Sex Related Differences in Retinal Pigment Epithelium and Retinal Disease

      • Gloriane Schnabolk, Elisabeth Obert, Bärbel Rohrer
      Pages 185-201
  4. The RPE in Diagnostics

    1. Front Matter

      Pages 203-203
    2. RPE in SD-OCT

      • Andrea Hassenstein, Carsten Grohmann
      Pages 205-232
    3. RPE Autofluorescence

      • Stefan Dithmar, Nil Celik
      Pages 233-245
  5. The RPE in Therapy

    1. Front Matter

      Pages 247-247
    2. RPE and Stem Cell Therapy

      • Heli Skottman
      Pages 249-263
    3. RPE and Gene Therapy

      • Knut Stieger, Birgit Lorenz
      Pages 265-279

About this book

This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models.

Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic. 

Editors and Affiliations

  • Department of Ophthalmology, University of Kiel, University Medical Center, Kiel, Germany

    Alexa Karina Klettner

  • Department of Ophthalmology HSK Wiesbaden, University of Mainz, Wiesbaden, Germany

    Stefan Dithmar

About the editors

Professor Alexa Klettner is head of laboratories at the Department of Ophthalmology, University Hospital Kiel and professor of experimental retinology at the Christian Albrecht University, Kiel, Germany. 

Professor Stefan Dithmar is Director and Chairman of the Department of Ophthalmology, HSK, Wiesbaden, University of Mainz, Germany.    

Bibliographic Information

  • Book Title: Retinal Pigment Epithelium in Health and Disease

  • Editors: Alexa Karina Klettner, Stefan Dithmar

  • DOI: https://doi.org/10.1007/978-3-030-28384-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-28383-4Published: 02 January 2020

  • Softcover ISBN: 978-3-030-28386-5Published: 26 August 2021

  • eBook ISBN: 978-3-030-28384-1Published: 01 January 2020

  • Edition Number: 1

  • Number of Pages: XI, 357

  • Number of Illustrations: 17 b/w illustrations, 100 illustrations in colour

  • Topics: Ophthalmology

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access