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Advances in Experimental Medicine and Biology

Retinal Degenerative Diseases

Mechanisms and Experimental Therapy

Editors: Bowes Rickman, C., Grimm, C., Anderson, R., Ash, J., LaVail, M.M., Hollyfield, J. (Eds.)

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About this book

This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke  and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.

The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.

The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.

 


Table of contents (95 chapters)

Table of contents (95 chapters)
  • AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia

    Pages 3-7

    Akhtar-Schaefer, Isha (et al.)

  • A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies

    Pages 9-13

    Choudhary, Mayur (et al.)

  • GPR143 Signaling and Retinal Degeneration

    Pages 15-19

    Figueroa, Anna G. (et al.)

  • Isolation of Retinal Exosome Biomarkers from Blood by Targeted Immunocapture

    Pages 21-25

    Klingeborn, Mikael (et al.)

  • Systemic Inflammatory Disease and AMD Comorbidity

    Pages 27-31

    Schnabolk, Gloriane

Buy this book

eBook $229.00
price for USA in USD (gross)
  • ISBN 978-3-030-27378-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.99
price for USA in USD
  • ISBN 978-3-030-27377-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Retinal Degenerative Diseases
Book Subtitle
Mechanisms and Experimental Therapy
Editors
  • Catherine Bowes Rickman
  • Christian Grimm
  • Robert Anderson
  • John Ash
  • Matthew M. LaVail
  • Joe Hollyfield
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1185
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-27378-1
DOI
10.1007/978-3-030-27378-1
Hardcover ISBN
978-3-030-27377-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 596
Number of Illustrations
43 b/w illustrations, 82 illustrations in colour
Topics

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