Overview
- Focuses on an unmet clinical need for gliomas, including early response and predictive imaging markers that have the potential to truly impact patient management decisions
- In depth coverage of advanced physiologic imaging, including CEST, pH imaging, hyperpolarized MR spectroscopy, and 2-HG detection (for IDH1 mutant tumors) with MRS
- Integrates imaging with the updated World Health Organization brain tumor classification system
- Includes exposition on the new FDA supported standardized brain tumor imaging protocol, required for imagers to participate in upcoming trials
- Covers of radiogenomics, radiomics, and machine learning, cutting edge “big data” approaches to improving imaging for cancer and other diseases
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Table of contents (17 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.
- current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
- the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
- the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
- about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
- of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits
Editors and Affiliations
About the editor
Whitney B. Pope, MD, PhD is Professor-in-Residence and Director of Brian Tumor Imaging in the Department of Radiological Sciences at the David Geffen School of Medicine at UCLA. He has served on the editorial board of several neurology and neuroradiology journals, including Neuro-Oncology. He has presented and published widely on brain tumor imaging.
Bibliographic Information
Book Title: Glioma Imaging
Book Subtitle: Physiologic, Metabolic, and Molecular Approaches
Editors: Whitney B. Pope
DOI: https://doi.org/10.1007/978-3-030-27359-0
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-27358-3Published: 21 November 2019
Softcover ISBN: 978-3-030-27361-3Published: 21 November 2020
eBook ISBN: 978-3-030-27359-0Published: 11 November 2019
Edition Number: 1
Number of Pages: XIV, 286
Number of Illustrations: 40 b/w illustrations, 69 illustrations in colour
Topics: Imaging / Radiology, Oncology