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Glioma Imaging

Physiologic, Metabolic, and Molecular Approaches

Editors: Pope, Whitney B. (Ed.)

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  • Focuses on an unmet clinical need for gliomas, including early response and predictive imaging markers that have the potential to truly impact patient management decisions
  • In depth coverage of advanced physiologic imaging, including CEST, pH imaging, hyperpolarized MR spectroscopy, and 2-HG detection (for IDH1 mutant tumors) with MRS
  • Integrates imaging with the updated World Health Organization brain tumor classification system
  • Includes exposition on the new FDA supported standardized brain tumor imaging protocol, required for imagers to participate in upcoming trials
  • Covers of radiogenomics, radiomics, and machine learning, cutting edge “big data” approaches to improving imaging for cancer and other diseases
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-27359-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-27358-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors.  Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.


The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management.  Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: 

  • current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
  • the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET 
  • the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
  • about  the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
  • of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

About the authors

Whitney B. Pope, MD, PhD is Professor-in-Residence and Director of Brian Tumor Imaging in the Department  of Radiological Sciences at the David Geffen School of Medicine at UCLA. He has served on the editorial board of several neurology and neuroradiology journals, including Neuro-Oncology. He has presented and published widely on brain tumor imaging.

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Indications and Limitations of Conventional Imaging – Current Clinical Practice in the Context of Standard Therapy

    Pages 1-15

    Huang, Raymond Y. (et al.)

  • Surrogates for Disease Status: Contrast Enhancement Including Limitations of Pseudoprogression and Pseudoresponse

    Pages 17-29

    Hattingen, Elke

  • The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma

    Pages 31-48

    Lupo, Janine M. (et al.)

  • Contrast-Enhanced T1-Weighted Digital Subtraction for Increased Lesion Conspicuity and Quantifying Treatment Response in Malignant Gliomas

    Pages 49-60

    Ellingson, Benjamin M.

  • Advanced Physiologic Imaging: Perfusion – Theory and Applications

    Pages 61-91

    Kickingereder, Philipp (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-27359-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-030-27358-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Glioma Imaging
Book Subtitle
Physiologic, Metabolic, and Molecular Approaches
Editors
  • Whitney B. Pope
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-27359-0
DOI
10.1007/978-3-030-27359-0
Hardcover ISBN
978-3-030-27358-3
Edition Number
1
Number of Pages
XIV, 286
Number of Illustrations
40 b/w illustrations, 69 illustrations in colour
Topics