Recent Results in Cancer Research

Tumor Liquid Biopsies

Editors: Schaffner, Florence, Merlin, Jean-Louis, von Bubnoff, Nikolas (Eds.)

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  • Describes the cutting-edge liquid biopsy technologies that promise to revolutionize oncology practice
  • Covers all basic approaches in the fields, with explanation of uses, benefits and limitations
  • Focuses on translational aspects
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About this book

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

About the authors

Florence Schaffner obtained her PhD in Cell Biology and Biochemistry in Freiburg-im-Breisgau (Germany), in Prof. Hellmut Augustin’s angiogenesis and tumor biology lab. There, she studied in depth the role of the interaction between the receptor EphB4 and its ligand ephrinB2 during tumor angiogenesis and metastatic processes and in particular tumor cell seeding at the site of metastasis. She then took up a postdoctoral research position at Scripps Research Institute in California, under Prof. Wolfram Ruf, where she investigated the role of coagulation proteins such as tissue factor and the protease-activated receptor in tumor angiogenesis, metastasis, and cancer stem cell biology. She continued her work on cancer stem cells in France, in Dr. Dontenwill’s lab in Strasbourg. She now works at the Cancéropôle Grand-East, where she is developing new and innovative research axes in relation to translational medicine.

Jean-Louis Merlin obtained his PharmD in Lille (France) and his PhD and Research Direction degree in Nancy (France), while working in Prof. Vigneron’s lab (Faculty of Pharmacy) on innovative anticancer drug targeting in liposomes and molecular mechanisms of drug resistance in preclinical models. While head of the research lab at the Alexis Vautrin Cancer Center (now the Institut de Cancérologie de Lorraine) in Nancy, he became Professor of Cellular Oncology at the Faculty of Pharmacy. There he set up the tumor biology unit to implement the analysis of molecular tumor genetic markers in the clinical management of cancer patients. Professor Merlin coordinates the Advanced Diagnostic and Translational Research project of the CNRS research unit (UMR 7039) and the Translational Research axis at Cancéropôle Grand-East. He is also coordinating several clinical trials aiming at the validation of circulating tumor DNA as an alternative to tumor DNA for molecular diagnosis and follow-up of patients with colorectal and breast cancer, and melanoma.

Nikolas von Bubnoff obtained his MD at the Ludwig Maximilian University in Munich and gained his postdoctoral qualification at the Technical University, Munich for work describing and characterizing secondary resistance mutations of the Bcr-Abl gene in CML. While a resident at Klinikum rechts der Isar (Munich) he continued working on molecular mechanisms of treatment resistance, establishing a cell line-based screening strategy for resistance to targeted cancer treatment. Professor von Bubnoff continued his work on circulating tumor (ct)DNA in gastrointestinal stromal tumors in Freiburg, where he established routine ctDNA testing in solid tumors. There, together with Robert Zeiser, he translated this preclinical work into clinical applications. Professor von Bubnoff is currently Deputy Medical Director of the Comprehensive Cancer Center Freiburg, where he has established a molecular tumor board to make use of genome analysis to guide treatment. He is currently coordinating clinical trials on ctDNA biomarkers, treatment optimization in CML, and ruxolitinib treatment of steroid-refractory GvHD.


 

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC

    Pages 3-24

    Todenhöfer, Tilman (et al.)

  • Circulating Tumor Cell Enrichment Technologies

    Pages 25-55

    Boya, Mert (et al.)

  • Genetic Analysis of Circulating Tumour Cells

    Pages 57-76

    Kolinsky, Michael Paul (et al.)

  • Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring

    Pages 77-88

    Kalinich, Mark (et al.)

  • Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis

    Pages 89-104

    Keomanee-Dizon, Kevin (et al.)

Buy this book

eBook $79.99
price for USA in USD (gross)
  • ISBN 978-3-030-26439-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.99
price for USA in USD
  • ISBN 978-3-030-26438-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Liquid Biopsies
Editors
  • Florence Schaffner
  • Jean-Louis Merlin
  • Nikolas von Bubnoff
Series Title
Recent Results in Cancer Research
Series Volume
215
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-26439-0
DOI
10.1007/978-3-030-26439-0
Hardcover ISBN
978-3-030-26438-3
Series ISSN
0080-0015
Edition Number
1
Number of Pages
VI, 368
Topics