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Contemporary Endocrinology

Insulin Resistance

Childhood Precursors of Adult Disease

Editors: Zeitler, Philip S., Nadeau, Kristen J. (Eds.)

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  • A revised and updated edition of the classic 2008 text on insulin resistance in the pediatric population and its impact across the lifespan
  • Discusses epidemiology, pathophysiology, molecular and metabolic mechanisms, unique models and management strategies for insulin resistance, as well as its relationship with cardiovascular and liver disorders
  • Includes chapters specifically on insulin resistance in patients with type 1 diabetes, children born small for their age and girls with polycystic ovary syndrome
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eBook $109.00
price for USA in USD
  • ISBN 978-3-030-25057-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
About this book

Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular disease and liver disorders.  A third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome. The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery.

Insulin Resistance: Childhood Precursors of Adult Disease, Second Edition provides up-to-date reviews of all of these areas, providing the reader with a current perspective on issues in insulin resistance in youth, an emerging risk factor for disease across the lifespan, that will spur continued interest in the topic on the part of clinicians and researchers, perhaps promoting new points of view and creative approaches to this daunting challenge.

About the authors

Philip S. Zeitler, MD, PhD, Professor, Department of Pediatrics-Endocrinology, University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO, USA

Kristen J. Nadeau, MD, MS, Associate Professor, Department of Pediatrics-Endocrinology, University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO, USA

Table of contents (20 chapters)

Table of contents (20 chapters)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-030-25057-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Insulin Resistance
Book Subtitle
Childhood Precursors of Adult Disease
Editors
  • Philip S. Zeitler
  • Kristen J. Nadeau
Series Title
Contemporary Endocrinology
Copyright
2020
Publisher
Humana Press
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-25057-7
DOI
10.1007/978-3-030-25057-7
Hardcover ISBN
978-3-030-25055-3
Series ISSN
2523-3785
Edition Number
2
Number of Pages
XVI, 356
Number of Illustrations
22 b/w illustrations, 19 illustrations in colour
Topics