Overview
- A revised and updated edition of the classic 2008 text on insulin resistance in the pediatric population and its impact across the lifespan
- Discusses epidemiology, pathophysiology, molecular and metabolic mechanisms, unique models and management strategies for insulin resistance, as well as its relationship with cardiovascular and liver disorders
- Includes chapters specifically on insulin resistance in patients with type 1 diabetes, children born small for their age and girls with polycystic ovary syndrome
Part of the book series: Contemporary Endocrinology (COE)
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Table of contents (20 chapters)
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Front Matter
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Definition and Epidemiology
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Front Matter
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Pathophysiology
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Front Matter
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Unique Models of Insulin Resistance in Youth
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Front Matter
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Keywords
About this book
Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular disease and liver disorders. A third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome. The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery.
Insulin Resistance: Childhood Precursors of Adult Disease, Second Edition provides up-to-date reviews of all of these areas, providing the reader with a current perspective on issues in insulin resistance in youth, an emerging risk factor for disease across the lifespan, that will spur continued interest in the topic on the part of clinicians and researchers, perhaps promoting new points of view and creative approaches to this daunting challenge.
Editors and Affiliations
About the editors
Philip S. Zeitler, MD, PhD, Professor, Department of Pediatrics-Endocrinology, University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO, USA
Kristen J. Nadeau, MD, MS, Associate Professor, Department of Pediatrics-Endocrinology, University of Colorado School of Medicine, Children’s Hospital Colorado, Aurora, CO, USA
Bibliographic Information
Book Title: Insulin Resistance
Book Subtitle: Childhood Precursors of Adult Disease
Editors: Philip S. Zeitler, Kristen J. Nadeau
Series Title: Contemporary Endocrinology
DOI: https://doi.org/10.1007/978-3-030-25057-7
Publisher: Humana Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-25055-3Published: 07 November 2019
eBook ISBN: 978-3-030-25057-7Published: 14 October 2019
Series ISSN: 2523-3785
Series E-ISSN: 2523-3793
Edition Number: 2
Number of Pages: XVI, 356
Number of Illustrations: 22 b/w illustrations, 19 illustrations in colour
Topics: Endocrinology, Diabetes, Pediatrics