- Reports on research in biomarkers of aging across molecular, cellular, immunological, and neurological factors
- Covers genetics and epigenetic aging markers, immunosenescence and inflammaging markers, and biological markers of aging and mortality
- Benefits researchers, practitioners and advanced students who work with biomarkers
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- About this book
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This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.
In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).
The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.
Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.
Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
- About the authors
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Prof. Alexey Moskalev is a Corresponding member of Russian Academy of Sciences, Doctor of Biology, the Head of the Laboratory of Geroprptective and Radioprotective Technologies in the Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, the Head of the Department of Ecology of the Syktyvkar State University named after Pitirim Sorokin, the Head of the Laboratory of Genetics of Aging and Longevity in the Moscow Institute of Physics and Technology.
- Table of contents (23 chapters)
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Introduction
Pages 1-4
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Practical Detection of Biological Age: Why It Is not a Trivial Task
Pages 7-21
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Biological Age is a Universal Marker of Aging, Stress, and Frailty
Pages 23-36
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Biomarkers of Health and Healthy Ageing from the Outside-In
Pages 37-46
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Epigenomic, Transcriptome and Image-Based Biomarkers of Aging
Pages 47-66
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Table of contents (23 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Biomarkers of Human Aging
- Editors
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- Alexey Moskalev
- Series Title
- Healthy Ageing and Longevity
- Series Volume
- 10
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-24970-0
- DOI
- 10.1007/978-3-030-24970-0
- Hardcover ISBN
- 978-3-030-24969-4
- Softcover ISBN
- 978-3-030-24972-4
- Series ISSN
- 2199-9007
- Edition Number
- 1
- Number of Pages
- VII, 421
- Number of Illustrations
- 5 b/w illustrations, 34 illustrations in colour
- Topics
