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  • © 2019

The Drosophila Model in Cancer

Editors:

  • Reviews use of the powerful Drosophila model for cancer studies from gene discovery to models of disease progression, to drug screening.
  • Highlights the challenges in cancer research and how the humble fruit-fly model can help
  • Offers guidance for researchers to develop new models, concepts and therapeutic strategies against cancer

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1167)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-vi
  2. Drosophila Model in Cancer: An Introduction

    • Deeptiman Chatterjee, Wu-Min Deng
    Pages 1-14
  3. Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function

    • Santiago Nahuel Villegas, Dolors Ferres-Marco, María Domínguez
    Pages 15-35
  4. Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis

    • Natasha Fahey-Lozano, John E. La Marca, Marta Portela, Helena E. Richardson
    Pages 37-64
  5. Autophagy and Tumorigenesis in Drosophila

    • Rojyar Khezri, Tor Erik Rusten
    Pages 113-127
  6. Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila

    • Xiao Li, Mengmeng Liu, Jun-Yuan Ji
    Pages 129-155
  7. MicroRNAs in Drosophila Cancer Models

    • Moritz Sander, Héctor Herranz
    Pages 157-173
  8. Cancer Stem Cells and Stem Cell Tumors in Drosophila

    • Shree Ram Singh, Poonam Aggarwal, Steven X. Hou
    Pages 175-190
  9. Drosophila as a Model for Tumor-Induced Organ Wasting

    • Pedro Saavedra, Norbert Perrimon
    Pages 191-205
  10. Drosophila melanogaster as a Model System for Human Glioblastomas

    • Alexander S. Chen, Renee D. Read
    Pages 207-224
  11. Correction to: Autophagy and Tumorigenesis in Drosophila

    • Rojyar Khezri, Tor Erik Rusten
    Pages C1-C1
  12. Back Matter

    Pages 249-250

About this book

This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics.  Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression.

 

Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use.  This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems.

 

This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, Tulane Cancer Center, LCRC, Tulane University School of Medicine, New Orleans, USA

    Wu-Min Deng

About the editor

Wu-Min Deng is a Professor at the Department of Biological Sciences in Florida State University.

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access