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  • © 2020

Central Nervous System Metastases

  • Focuses on the topic of brain metastases
  • Provides a comprehensive guide to brain metastasis pathophysiology and management
  • Presents new therapeutic strategies, such as surgical techniques, radiation therapy techniques and new systemic treatment approaches, including targeted- and immunotherapy

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xiii
  2. Epidemiology, Pathology and Molecular Biology

    1. Front Matter

      Pages 1-1
    2. Epidemiology of Central Nervous System Metastases

      • Linda Dirven, Martin J. B. Taphoorn
      Pages 3-14
    3. Pathology of Brain Metastasis

      • Dana A. Mustafa, Rute Pedrosa, Johan M. Kros
      Pages 15-29
    4. Molecular Mechanisms in Brain Metastasis

      • Ekrem Emrah Er, Adrienne Boire
      Pages 31-41
    5. Genomic Characterization of Brain Metastases: Implications for Precision Medicine

      • Franziska M. Ippen, Elisa Aquilanti, Helen D’Couto, Julia Grosch, Priscilla K. Brastianos
      Pages 43-58
    6. Brain Metastases Cell Partners and Tumor Microenvironment

      • Pedro García-Gómez, Neibla Priego, Laura Álvaro-Espinosa, Manuel Valiente
      Pages 59-71
    7. Liquid Biopsy Diagnosis of CNS Metastases

      • Mafalda Antunes Ferreira, Silvia D’Ambrosi, Thomas Würdinger, Pieter Wesseling, Danijela Koppers-Lalic
      Pages 73-86
    8. Preclinical Models of Brain Metastases

      • Alex Wu, Anurag N. Paranjape, Brunilde Gril
      Pages 87-105
  3. Clinical/Radiological Presentation and Management

    1. Front Matter

      Pages 107-107
    2. Clinical Presentation of Brain Metastases

      • Annette Compter, Dieta Brandsma
      Pages 109-115
    3. Epilepsy in CNS Metastases

      • Roberta Rudà, Alessia Pellerino, Riccardo Soffietti
      Pages 117-125
    4. Safety, Tolerability, and Use of Steroids

      • Fabian Wolpert, Patrick Roth
      Pages 127-137
    5. Anticoagulation in Patients with Brain Metastases

      • Christine Marosi, Cihan Ay
      Pages 139-143
    6. Imaging of Brain Metastases: Diagnosis and Monitoring

      • Gabriel C. T. E. Garcia, Sophie Bockel, Michaël Majer, Samy Ammari, Marion Smits
      Pages 145-158
    7. Metabolic Imaging of Brain Metastasis

      • Norbert Galldiks, Bogdana Suchorska, Nathalie L. Albert, Jörg C. Tonn
      Pages 159-171
  4. Surgery, Radiation Therapy and Systemic Treatments

    1. Front Matter

      Pages 181-181
    2. Surgery in Brain Metastasis Management: Therapeutic, Diagnostic, and Strategic Considerations

      • Philippe Metellus, Johan Pallud, Zvi Ram, Colin Watts, Manfred Westphal
      Pages 183-190
    3. Surgical Resection for Brain Metastases

      • Ali S. Haider, Raymond Sawaya, Sherise D. Ferguson
      Pages 191-198

About this book

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.

Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.

Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

 

Editors and Affiliations

  • Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, USA

    Manmeet Ahluwalia

  • Department of Neurosurgery and Neuro-Oncology, Clairval Hospital Center, Ramsay-Générale de Santé, Marseille, France, Neurophysiopathology Institute, Aix-Marseille Université, Marseille, France

    Philippe Metellus

  • Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy

    Riccardo Soffietti

About the editors

Manmeet Ahluwalia is a Medical Oncology specialist at Cleveland Clinic, Ohio, USA. His specialties include Hematology, Oncology, Internal Medicine and Medical Oncology. He is subspecialized in the treatment of patients with brain tumors and brain metastases. He is the Director of the Brain Metastasis Research Program and Head of Operations in the BBTC of the Neurological Institute of Cleveland Clinic. Dr. Ahluwalia is a fellow of the American College of Physicians and has served in multiple leadership positions in various professional societies. His research focuses on the development of new therapies for patients with brain tumors and brain metastases. He has published over 160 peer-reviewed articles and received substantial awards.

Philippe Metellus is Professor of Neurosurgery at the Clairval Hospital Center in Marseille, France. He is specialized in brain tumors and is the actual leader of the Glioma and the Brain Metastases program in France. Prof. Metellus has authored or co-authored more than 150 peer-reviewed articles. He is also a reviewer for a number of international journals and is a member of multiple professional societies. Further, he is involved in a multi-disciplinary translational research program on gliomas and brain metasteses with the oncological transfer laboratory at the Aix-Marseille University. Since 2011, Prof Metellus has organized the « Annual Brain Metastases Research and Emerging Therapies Conference in Brain Metastasis » in Marseille, under the auspices of EORTC and with the support of French (ANOCEF and SNCF) and European (EANO and EANS) societies.

Riccardo Soffietti is Professor of Neurology and Neuro-Oncology at the University Hospital of Turin, Italy. He is specialized in Neuro-Oncology for the diagnosis and treatment of primary and secondary brain tumors. He was a Founding Member of the European Association of Neuro-Oncology (EANO) and its President from 2012 to 2014. Prof. Soffietti was President of the Italian Association of Neuro-Oncology (AINO) and is Chairperson of the Panel of Neuro-Oncology of the European Academy of Neurology (EAN). Prof. Soffietti has authored or co-authored over 170 peer-reviewed articles, 40 chapters in books and 8 books. He received major awards for coordinating a variety of clinical and translational research projects. He is also Reviewer, Editor or Member of the editorial boards of several international journals. He is a Member of Brain Tumor Group of the EORTC and of the International Group on Response Assessment in Neuro-Oncology (RANO). 



Bibliographic Information

  • Book Title: Central Nervous System Metastases

  • Editors: Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti

  • DOI: https://doi.org/10.1007/978-3-030-23417-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-23416-4Published: 15 November 2019

  • Softcover ISBN: 978-3-030-23419-5Published: 15 November 2020

  • eBook ISBN: 978-3-030-23417-1Published: 05 November 2019

  • Edition Number: 1

  • Number of Pages: XIII, 421

  • Number of Illustrations: 8 b/w illustrations, 37 illustrations in colour

  • Topics: Neurosurgery, Radiotherapy, Oncology, Cancer Research, Quality of Life Research

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access