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Diminished Ovarian Reserve and Assisted Reproductive Technologies

Current Research and Clinical Management

  • Book
  • © 2020

Overview

Editors:
  1. Orhan Bukulmez

    1. Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, USA

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  • Presents both the current research and the latest clinical approaches to management of diminished ovarian reserve (DOR)

  • Discusses definitions, natural history, and dietary and hormonal supplements, and reviews the current ovarian stimulation protocols, alternatives and outcomes

  • An excellent resource for reproductive medicine and REI specialists, IVF lab professionals, and residents in students

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. The Paradigm of Diminished Ovarian Reserve, Conventional & Adjuvant Treatment Approaches for Assisted Reproductive Technologies

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Introduction: The Scope of the Problem with Diminished Ovarian Reserve

      • Orhan Bukulmez
      Pages 3-11

    3. Ovarian and Hypothalamic Aging

      • Alexander Kucherov, Erkan Buyuk
      Pages 13-38

    4. Natural History of Diminished Ovarian Reserve

      • Orhan Bukulmez
      Pages 39-53

    5. Definitions and Relevance: Diminished Ovarian Reserve, Poor Ovarian Response, Advanced Reproductive Age, and Premature Ovarian Insufficiency

      • Orhan Bukulmez
      Pages 55-61

    6. Food Supplements and Hormonal Products to Improve Assisted Reproductive Technology Outcomes in Patients with Diminished Ovarian Reserve

      • Volkan Turan, Melis Bozan, Gurkan Bozdag
      Pages 63-74

    7. Traditional Chinese Medicine for Assisted Reproductive Technology

      • Wei Shang
      Pages 75-104

    8. Controlled Ovarian Stimulation Protocols for IVF: From First IVF Baby in the United States and Beyond

      • Hakan E. Duran
      Pages 105-117

    9. Conventional Controlled Ovarian Stimulation Protocols for Diminished Ovarian Reserve Patients and Poor Responders

      • Bala Bhagavath
      Pages 119-129

    10. Natural Cycle Approaches for ART

      • Jennifer Shannon
      Pages 131-137

  3. Minimal and Mild Stimulation Protocols

    1. Front Matter

      Pages 139-139
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    2. The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) Definitions for Mild Stimulation and Their Rationale for Assisted Reproductive Technologies

      • Orhan Bukulmez
      Pages 141-149

    3. Current Outlook of Minimal and Mild Stimulation Protocols for Assisted Reproductive Technologies in Women with Diminished Ovarian Reserve and/or Advanced Reproductive Age

      • Orhan Bukulmez
      Pages 151-155

    4. Minimal Stimulation Protocol for Assisted Reproductive Technologies in Women with Diminished Ovarian Reserve and/or Advanced Reproductive Age

      • Orhan Bukulmez
      Pages 157-174

    5. Mild Stimulation Alternatives to Minimal Stimulation

      • Orhan Bukulmez
      Pages 175-183

    6. Control of Luteinizing Hormone (LH)

      • Beverly G. Reed
      Pages 185-193

    7. Preventing Premature Ovulation

      • Orhan Bukulmez
      Pages 195-200

    8. Trigger Agents and Post-trigger Testing

      • John Wu, David Prokai, Orhan Bukulmez
      Pages 201-208

    9. Oocyte Retrieval

      • John Wu
      Pages 209-219
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Keywords

About this book

This book brings together the most current research and the latest clinical approaches to the management of diminished ovarian reserve (DOR), one of the largest segments of the IVF patient population, both in the advanced reproductive age group as well as poor responders. Opening with a review of the definition and scope of the problem, as well as the current understanding of the natural history of DOR, subsequent chapters in part I outline dietary, hormonal, traditional supplements and conventional methods used to stimulate ovaries and improve ART outcomes. The main segment of chapters, comprising part II, present minimal and mild stimulation protocols and alternatives, frozen embryo transfer preparation, trigger agents and post-trigger testing, embryo culture and endometrial considerations, and a review of clinical outcomes. Part III discusses the utilization of contemporary technologies in the treatment of DOR, including fresh vs. frozen embryo transfer, cryopreservation and comprehensive chromosomal analysis. Future prospects are presented in part IV, such as the artificial oocyte and ovary development, early-age oocyte freezing, ovarian cortical tissue freezing and activation of the ovarian cortex.


Utilizing the latest evidence and authored by an international array of thought leaders, Diminished Ovarian Reserve and Assisted Reproductive Technologies is an excellent resource for reproductive medicine and REI specialists, IVF lab professionals, and students and residents in these areas.


Editors and Affiliations

  • Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, USA

    Orhan Bukulmez

About the editor

Orhan Bukulmez, MD, Associate Professor and Division Director, Division of Reproductive Endocrinology and Infertility; Practice and Medical Director, Fertility and Advanced Reproductive Medicine Assisted Reproductive Technology Program; Medical Director, UT Southwestern Fertility Clinic; Chief, Gynecologic Endocrinology Service, Parkland Health and Hospital System; Department of Obstetrics and Gynecology,  University of Texas Southwestern Medical Center, Dallas, TX, USA

Bibliographic Information

  • Book Title: Diminished Ovarian Reserve and Assisted Reproductive Technologies

  • Book Subtitle: Current Research and Clinical Management

  • Editors: Orhan Bukulmez

  • DOI: https://doi.org/10.1007/978-3-030-23235-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-23234-4Published: 15 October 2019

  • Softcover ISBN: 978-3-030-23237-5Published: 15 October 2020

  • eBook ISBN: 978-3-030-23235-1Published: 01 October 2019

  • Edition Number: 1

  • Number of Pages: XX, 360

  • Number of Illustrations: 16 b/w illustrations, 31 illustrations in colour

  • Topics: Reproductive Medicine, Endocrinology

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