Results and Problems in Cell Differentiation

The Golgi Apparatus and Centriole

Functions, Interactions and Role in Disease

Editors: Kloc, Malgorzata (Ed.)

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  • First book to address the interactions between the Golgi complex and the centriole 
  • Describes the roles of Golgi complex and centriole in cellular functions and diseases 
  • Outlines how a better understanding of the Golgi–centriole interactions may lead to novel therapies for various diseases
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  • ISBN 978-3-030-23173-6
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Hardcover $249.99
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  • Usually dispatched within 3 to 5 business days.
About this book

This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.

Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. 

This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.

 

About the authors

Dr. Malgorzata Kloc completed her PhD in Poland on insect oogenesis, and worked as a tenured Assistant Professor at University of Warsaw. In 1981, she immigrated to Canada and received fellowship from Alberta Heritage Foundation at Calgary University, Alberta, where she studied the heat shock proteins in Xenopus oocytes, and later at Saint Mary’s university in Halifax, Nova Scotia, and after that at Dalhousie University in Halifax where she received Terry Fox Foundation fellowship in molecular biology. In 1987, she moved to Houston, USA and worked at MD Anderson Cancer Center on Xenopus germ cell specification and development, and localized mRNA and cytoskeleton.  She left MD Anderson in the rank of Associate Professor in 2007 and moved to Houston Methodist Hospital and Research Institute where she currently has a rank of Weill Cornell Professor of cell and molecular biology. At Methodist she studies the role of macrophages, cytoskeleton and RhoA pathway in development of chronic rejection of transplanted organs.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis

    Pages 3-15

    Avidor-Reiss, Tomer (et al.)

  • The Role of Protein Acetylation in Centrosome Biology

    Pages 17-25

    Hossain, Delowar (et al.)

  • Formins, Golgi, and the Centriole

    Pages 27-48

    Copeland, John

  • Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon

    Pages 49-79

    Mironov, Alexander A. (et al.)

  • RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex

    Pages 81-93

    Kloc, Malgorzata (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-030-23173-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-030-23172-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Golgi Apparatus and Centriole
Book Subtitle
Functions, Interactions and Role in Disease
Editors
  • Malgorzata Kloc
Series Title
Results and Problems in Cell Differentiation
Series Volume
67
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-23173-6
DOI
10.1007/978-3-030-23173-6
Hardcover ISBN
978-3-030-23172-9
Series ISSN
0080-1844
Edition Number
1
Number of Pages
XIX, 529
Number of Illustrations
2 b/w illustrations, 63 illustrations in colour
Topics