- Combines the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging
- Describes label-free super-resolution microscopy
- Introduces also the important topic super-resolved fluorescence microscopy
- Presents the applications of label-free super-resolution imaging
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- About this book
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This book presents the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging. In the last decade, super-resolved fluorescence imaging has opened new horizons in improving the resolution of optical microscopes far beyond the classical diffraction limit, leading to the Nobel Prize in Chemistry in 2014. This book represents the first comprehensive review of a different type of super-resolved microscopy, which does not rely on using fluorescent markers. Such label-free super-resolution microscopy enables potentially even broader applications in life sciences and nanoscale imaging, but is much more challenging and it is based on different physical concepts and approaches. A unique feature of this book is that it combines insights into mechanisms of label-free super-resolution with a vast range of applications from fast imaging of living cells to inorganic nanostructures. This book can be used by researchers in biological and medical physics. Due to its logically organizational structure, it can be also used as a teaching tool in graduate and upper-division undergraduate-level courses devoted to super-resolved microscopy, nanoscale imaging, microscopy instrumentation, and biomedical imaging.
- About the authors
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Vasily N. Astratov has been professor of Physics and Optical Science at the University of North Carolina-Charlotte since 2002. In 1986, he received his Ph.D. degree from the A.F. Ioffe Physical-Technical Institute in Russia. Since joining UNC-Charlotte in 2002, his research has been devoted to a new field of study which he has named "microspherical photonics" to describe the applications of dielectric microspheres in super-resolution microscopy, resonant light forces, photonic nanojets, and photonic molecules. In his lab, he proposed and developed the methods of super-resolution imaging based on using high-index dielectric microspheres immersed in liquids or in elastomeric slabs. His methods are widely used by many groups worldwide for imaging subcellular structures, viruses, and nanoplasmonic structures. He also observed giant light forces exerted on microspheres under resonant conditions with their whispering gallery modes. This observation builds upon earlier pioneering work of Arthur Ashkin and Joseph M. Dziedzic on optical forces exerted on microdroplets. Previously, in the mid-1990s he pioneered studies of synthetic opals as novel three-dimensional photonic crystals for visible light. He has authored and co-authored about 180 research publications and 15 patents which have been cited more than 6000 times.
- Table of contents (17 chapters)
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Quantitative Phase Imaging: Principles and Applications
Pages 1-24
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Interferometric Scattering (iSCAT) Microscopy and Related Techniques
Pages 25-65
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Label-Free, Ultrahigh-Speed, Direct Imaging and Tracking of Bionanoparticles in Live Cells by Using Coherent Brightfield Microscopy
Pages 67-84
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Tomographic Diffractive Microscopy: Principles, Implementations, and Applications in Biology
Pages 85-112
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Near-Field Scanning Optical Microscope Combined with Digital Holography for Three-Dimensional Electromagnetic Field Reconstruction
Pages 113-136
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Table of contents (17 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Label-Free Super-Resolution Microscopy
- Editors
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- Vasily Astratov
- Series Title
- Biological and Medical Physics, Biomedical Engineering
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-21722-8
- DOI
- 10.1007/978-3-030-21722-8
- Hardcover ISBN
- 978-3-030-21721-1
- Series ISSN
- 1618-7210
- Edition Number
- 1
- Number of Pages
- XXII, 487
- Number of Illustrations
- 22 b/w illustrations, 222 illustrations in colour
- Topics
