Cardiorenal Syndrome in Heart Failure

This comprehensive manual reviews the management of cardiorenal syndrome in heart failure. Chapters are structured in a practically applicable and easy-to-follow format with realistic case vignettes and key clinical management questions and answers, followed by a brief discussion of underlying pathophysiological mechanisms of a patient with cardiorenal syndrome. Building from this case, key questions are posed that are relevant to the clinical management and then potential evidence-based treatment strategies are proposed. Topics covered include loop diuretic resistance in acute and chronic heart failure, abdominal congestion, low output failure and potential diuretic complications due to hyponatremia. 

Cardiorenal Syndrome in Heart Failure thoroughly reviews cardiorenal syndrome from the perspective of both the cardiologist and nephrologist. Its case-based approach makes it an ideal resource for both practising and trainee cardiology and nephrology practitioners. 

• Cardio-Renal Syndrome
• Loop diuretic resistance
• Heart Failure
• Diuretics
• Ultrafiltration
• chronic kidney disease
• hyponatremia
• right heart failure

• Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, USA

  W. H. Wilson Tang

• Department of Internal Medicine, UZ Leuven, Leuven, Belgium

  Frederik H. Verbrugge

• Ziekenhuis Oost-Limburg, Genk University Hasselt, Genk, Belgium

  Wilfried Mullens

W.H. Wilson Tang is research director and staff cardiologist in the Section of Heart Failure and Cardiac Transplantation Medicine at the Heart and Vascular Institute, Cleveland Clinic, U.S.A. As a clinician-scientist and practicing heart failure/transplant cardiologist specialized in cardiomyopathies and kidney-/cancer-related heart diseases, Dr. Tang's translational research focuses on understanding the cellular and molecular mechanisms that contribute to disease progression in heart failure and cardio-renal diseases.  He has been elected as member of the American Society of Clinical Investigation in 2013 for his contributions to mechanistic understanding of cardio-renal syndromes, and the Association of American Physicians in 2018 for studying the contributing role of diet and microbiome in cardiovascular diseases.  Dr. Tang has authored over 600 peer-reviewed scientific publications, editorials, and book chapters, and has served as Board of Directors in the Heart Failure Society of America (HFSA), as well as member of the writing committee for American College of Cardiology (ACC)/American Heart Association (AHA) clinical guidelines in the management of heart failure. 

Frederik H. Verbrugge is a cardiologist with a dedicated interest in heart failure, hemodynamics and renal physiology. Dr. Verbrugge graduated as an M.D. in 2010 and obtained his Ph.D. degree in 2015 with his doctoral thesis entitled “Phenotyping the heart failure syndrome: towards individualized patient care”. He is currently a research fellow at Mayo Clinic (Rochester, MN, USA) and has published over 70 peer-reviewed articles in the field of cardiology and heart failure.

Wilfried Mullens is cardiologist and professor of physiology at Ziekenhuis Oost-Limburg (Genk, Belgium) and Hasselt University (Diepenbeek, Belgium), respectively. Prof. Mullens has published over 150 peer-reviewed articles, has been president of the Belgian Working Group on Heart Failure (BWGHF), Coordinator of the CardioRenal Study group of the European Heart Failure Association (HFA), and board member of the HFA.

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