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Studies in Mechanobiology, Tissue Engineering and Biomaterials

Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Editors: Zhang, Katherine Yanhang (Ed.)

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  • Broadens readers’ understanding of the importance of structure–function perspectives on soft biological tissue
  • Enhances our understanding of integrated, multi-scale experimental and modeling approaches in biological science
  • Reviews the key recent research on ECM mechanics and mechanobiology using state-of-the-art technologies in computational modeling, advanced optical imaging, and biomechanical characterization
  • Maximizes readers’ insights into the hierarchical, multi-scale nature of ECM in governing cell and tissue behaviors
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-20182-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-030-20181-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms. 

About the authors

Dr. Yanhang (Katherine) Zhang is a Professor at Boston University’s Departments of Mechanical and Biomedical Engineering, and Division of Materials Science and Engineering. She received her double major B.S. degrees in Engineering Mechanics and Economics and Management from Tsinghua University, China, in 1998; and her M.S. and Ph.D. degrees in Mechanical Engineering from the University of Colorado at Boulder, in 2000 and 2003 respectively, and was also a postdoc there for two years. In 2006, Dr. Zhang became an Assistant Professor at Boston University, where she established the Multi-Scale Tissue Biomechanics Laboratory. Her research focuses on vascular biomechanics and the multi-scale mechanics and mechanobiology of the extracellular matrix. Her research has been funded the by National Institute of Health (NIH), National Science Foundation (NSF), and the Defense Advanced Research Projects Agency (DARPA). Dr. Zhang was awarded the Clare Boothe Luce Assistant Professorship from 2006–2011, and received the Young Faculty Award from DARPA in 2007, and Faculty Early Career Development (CAREER) Award from the NSF in 2010. Dr. Zhang was elected a Fellow of the American Society of Mechanical Engineers (ASME) in 2018.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Biomechanics and Mechanobiology of Extracellular Matrix Remodeling

    Pages 1-20

    Humphrey, Jay D. (et al.)

  • Multi-scale Modeling of the Heart Valve Interstitial Cell

    Pages 21-53

    Khang, Alex (et al.)

  • Modeling the Structural and Mechanical Properties of the Normal and Aneurysmatic Aortic Wall

    Pages 55-82

    Gasser, T. Christian

  • Cellular and Extracellular Homeostasis in Fluctuating Mechanical Environments

    Pages 83-121

    Suki, Béla (et al.)

  • Experimental Characterization of Adventitial Collagen Fiber Kinematics Using Second-Harmonic Generation Imaging Microscopy: Similarities and Differences Across Arteries, Species and Testing Conditions

    Pages 123-164

    Cavinato, Cristina (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-20182-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-030-20181-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Multi-scale Extracellular Matrix Mechanics and Mechanobiology
Editors
  • Katherine Yanhang Zhang
Series Title
Studies in Mechanobiology, Tissue Engineering and Biomaterials
Series Volume
23
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-20182-1
DOI
10.1007/978-3-030-20182-1
Hardcover ISBN
978-3-030-20181-4
Series ISSN
1868-2006
Edition Number
1
Number of Pages
XIII, 392
Number of Illustrations
19 b/w illustrations, 107 illustrations in colour
Topics