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Advances in Experimental Medicine and Biology

The mRNA Metabolism in Human Disease

Editors: Romão, Luísa (Ed.)

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  • Highlights recent advances in understanding the mRNA metabolism in human cells
  • Surveys representative examples of human diseases that result from defects/modifications affecting different steps of the mRNA metabolism
  •  Provides insight on potential RNA-based therapeutic strategies
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-030-19966-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-19965-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. 

This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.

About the authors

Luisa Romao is a principal investigator on the unit of hemoglobinopathies in the center of human genetics of the National Institute of Health Dr. Ricardo Jorge in Lisbon. She is a member of the RNA society. 

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease

    Pages 1-27

    Jordan, Peter (et al.)

  • The Diverse Roles of RNA-Binding Proteins in Glioma Development

    Pages 29-39

    Velasco, Mitzli X. (et al.)

  • Nonsense-Mediated mRNA Decay in Development, Stress and Cancer

    Pages 41-83

    Fernandes, Rafael (et al.)

  • The Implication of mRNA Degradation Disorders on Human DISease: Focus on DIS3 and DIS3-Like Enzymes

    Pages 85-98

    Saramago, Margarida (et al.)

  • Translational Regulation by Upstream Open Reading Frames and Human Diseases

    Pages 99-116

    Silva, Joana (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-030-19966-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-19965-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The mRNA Metabolism in Human Disease
Editors
  • Luísa Romão
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1157
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-19966-1
DOI
10.1007/978-3-030-19966-1
Hardcover ISBN
978-3-030-19965-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 180
Number of Illustrations
1 b/w illustrations, 17 illustrations in colour
Topics