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Efficacy Analysis in Clinical Trials an Update

Efficacy Analysis in an Era of Machine Learning

Authors: Cleophas, Ton J., Zwinderman, Aeilko H.

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  • It shows, for the first time, that machine learning methodologies can be used for assessing efficacy data of controlled clinical trials
  • It confirms, that machine learning methodologies provide better sensitivity of testing
  • It confirms, that machine learning methodologies are more informative
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eBook $89.00
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  • ISBN 978-3-030-19918-0
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Hardcover $119.99
price for USA in USD
  • ISBN 978-3-030-19917-3
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About this Textbook

Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variables

Modern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required

This is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are included

The authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do


About the authors

The authors are well-qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015), and Professor Cleophas is past-president of the American College of Angiology (2000-2002). 
Professor Zwinderman is one of the Principle Investigators of the Academic Medical Center Amsterdam, and his research is concerned with developing statistical methods for new research designs in biomedical science, particularly integrating omics data, like genomics, proteomics, metabolomics, and analysis tools based on parallel computing and the use of cluster computers and grid computing.   
Professor Cleophas is a member of the Academic Committee of the European College of Pharmaceutical Medicine, that provides, on behalf of 22 European Universities, the Master-ship trainings  "Pharmaceutical Medicine" and "Medicines Development".  
From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 18 years, and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
The authors as professors and teachers in statistics at universities in The Netherlands and France for the most part of their lives, are concerned, that their students find regression-analyses harder than any other methodology in statistics. This is serious, because almost all of the novel methodologies in current data mining and data analysis include elements of regression-analysis, and they do hope that the current production "Regression Analysis for Starters and 2nd Levelers" will be a helpful companion for the purpose. Five textbooks complementary to the current production and written by the same authors are 
Statistics applied to clinical studies 5th edition, 2012, Machine learning in medicine a complete overview, 2015, SPSS for starters and 2nd levelers 2nd edition, 2015, Clinical data analysis on a pocket calculator 2nd edition, 2016, Modern Meta-analysis, 2017Regression Analysis in Medical Research, 2018 all of them published by Springer 

Table of contents (20 chapters)

Table of contents (20 chapters)

Buy this book

eBook $89.00
price for USA in USD (gross)
  • ISBN 978-3-030-19918-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $119.99
price for USA in USD
  • ISBN 978-3-030-19917-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Efficacy Analysis in Clinical Trials an Update
Book Subtitle
Efficacy Analysis in an Era of Machine Learning
Authors
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-19918-0
DOI
10.1007/978-3-030-19918-0
Hardcover ISBN
978-3-030-19917-3
Edition Number
1
Number of Pages
XI, 304
Number of Illustrations
251 b/w illustrations, 44 illustrations in colour
Topics