Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

1. Front Matter

   Pages i-vi

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2. Transnasal Induction of Therapeutic Hypothermia for Neuroprotection

   • Raghuram Chava, Harikrishna Tandri

   Pages 1-7

3. Hypoxia-Primed Stem Cell Transplantation in Stroke

   • Zheng Zachory Wei, James Ya Zhang, Ling Wei

   Pages 9-26

4. Therapeutic Potential of Intranasal Drug Delivery in Preclinical Studies of Ischemic Stroke and Intracerebral Hemorrhage

   • Qian Li, Claire F. Levine, Jian Wang

   Pages 27-42

5. Intranasal Drug Delivery After Intracerebral Hemorrhage

   • Jing Chen-Roetling, Raymond F. Regan

   Pages 43-55

6. Intranasal Treatment in Subarachnoid Hemorrhage

   • Basak Caner

   Pages 57-64

7. Intranasal Delivery of Therapeutic Peptides for Treatment of Ischemic Brain Injury

   • Tingting Huang, Amanda Smith, Jun Chen, Peiying Li

   Pages 65-73

8. Intranasal Delivering Method in the Treatment of Ischemic Stroke

   • Chunhua Chen, Mengqin Zhang, Yejun Wu, Changman Zhou, Renyu Liu

   Pages 75-89

9. Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A

   • Yun Lin, Jiancheng Zhang, Jian Wang

   Pages 91-99

10. Intranasal tPA Application for Axonal Remodeling in Rodent Stroke and Traumatic Brain Injury Models

    • Zhongwu Liu, Ye Xiong, Michael Chopp

    Pages 101-115

11. Therapeutic Intranasal Delivery for Alzheimer’s Disease

    • Xinxin Wang, Fangxia Guan

    Pages 117-133

12. Intranasal Medication Delivery in Children for Brain Disorders

    • Gang Zhang, Myles R. McCrary, Ling Wei

    Pages 135-147

13. Back Matter

    Pages 149-153

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The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.​

• blood-brain-barrier
• intranasal delivery
• neuroregeneration
• stem cells
• stroke

• Department of Neurology, University of Pittsburgh, Pittsburgh, USA

  Jun Chen

• Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA

  Jian Wang

• Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, USA

  Ling Wei

• Department of Physiology, Loma Linda University School of Medicine, Loma Linda, USA

  John H. Zhang

Policies and ethics