Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori
Editors: Backert, Steffen (Ed.)
Free Preview- Broadens the reader’s understanding of host-pathogen interactions regarding Helicobacter pylori
- Provides new insights into the context of gastric inflammation and carcinogenesis
- Reviews the impact of H. pylori virulence factors on the host’s immune system
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- About this book
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This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.
This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.
- About the authors
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Prof. Dr. rer. nat. Steffen Backert
Chair of Microbiology
Friedrich Alexander University Erlangen/Nuremberg
Department of Biology
Division of Microbiology
Staudtstr. 5
D-91058 Erlangen
Germany
Tel. ++49 9131 8528081
Fax ++49 9131 8528082
- Table of contents (13 chapters)
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Inflammation, Immunity, and Vaccine Development for the Gastric Pathogen Helicobacter pylori
Pages 1-19
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Impact of Helicobacter pylori Virulence Factors on the Host Immune Response and Gastric Pathology
Pages 21-52
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Genetic Polymorphisms in Inflammatory and Other Regulators in Gastric Cancer: Risks and Clinical Consequences
Pages 53-76
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MALT Lymphoma as a Model of Chronic Inflammation-Induced Gastric Tumor Development
Pages 77-106
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Crosstalk Between DNA Damage and Inflammation in the Multiple Steps of Gastric Carcinogenesis
Pages 107-137
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Table of contents (13 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori
- Editors
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- Steffen Backert
- Series Title
- Current Topics in Microbiology and Immunology
- Series Volume
- 421
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-15138-6
- DOI
- 10.1007/978-3-030-15138-6
- Hardcover ISBN
- 978-3-030-15137-9
- Softcover ISBN
- 978-3-030-15140-9
- Series ISSN
- 0070-217X
- Edition Number
- 1
- Number of Pages
- XXIV, 359
- Number of Illustrations
- 1 b/w illustrations, 28 illustrations in colour
- Topics
