The DNA, RNA, and Histone Methylomes
Editors: Jurga, Stefan, Barciszewski, Jan (Eds.)
Free Preview- Comprehensively reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases
- Highlights clinical applications of epigenetic editing in cancer treatment and aging
- Highlights hot topics such as cellular plasticity, novel biomarkers and genome-wide association studies
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- About this book
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This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.
Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.
This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
- About the authors
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Prof. Dr. hab. Stefan Jurga,
Adam Mickiewicz University, Nanobiomedical Center,
Poznań, Poland
stjurga@amu.edu.pl
Prof. Dr.hab Jan Barciszewski,Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland and
Adam Mickiewicz University, Nanobiomedical Center, Poznań, Poland
jan.barciszewski@ibch.poznan.pl
- Table of contents (24 chapters)
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Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells
Pages 1-26
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Origin and Mechanisms of DNA Methylation Dynamics in Cancers
Pages 27-52
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CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers
Pages 53-62
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Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders
Pages 63-102
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DNA Methylation in Neuronal Development and Disease
Pages 103-140
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Table of contents (24 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- The DNA, RNA, and Histone Methylomes
- Editors
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- Stefan Jurga
- Jan Barciszewski
- Series Title
- RNA Technologies
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-14792-1
- DOI
- 10.1007/978-3-030-14792-1
- Hardcover ISBN
- 978-3-030-14791-4
- Softcover ISBN
- 978-3-030-14794-5
- Series ISSN
- 2197-9731
- Edition Number
- 1
- Number of Pages
- XI, 624
- Number of Illustrations
- 21 b/w illustrations, 57 illustrations in colour
- Topics
