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RNA Technologies

The DNA, RNA, and Histone Methylomes

Editors: Jurga, Stefan, Barciszewski, Jan (Eds.)

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  • Comprehensively reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases
  • Highlights clinical applications of epigenetic editing in cancer treatment and aging
  • Highlights hot topics such as cellular plasticity, novel biomarkers and genome-wide association studies
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eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-14792-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-030-14791-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.

Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.

This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


About the authors

Prof. Dr. hab.  Stefan Jurga, 

Adam Mickiewicz University, Nanobiomedical Center,

Poznań, Poland

stjurga@amu.edu.pl

Prof. Dr.hab Jan Barciszewski, 

Institute of Bioorganic Chemistry of the Polish Academy  of Sciences, Poznań, Poland and

Adam Mickiewicz University, Nanobiomedical Center, Poznań, Poland

jan.barciszewski@ibch.poznan.pl

Table of contents (24 chapters)

Table of contents (24 chapters)
  • Establishment, Erasure and Synthetic Reprogramming of DNA Methylation in Mammalian Cells

    Pages 1-26

    Jurkowska, Renata Z. (et al.)

  • Origin and Mechanisms of DNA Methylation Dynamics in Cancers

    Pages 27-52

    Easwaran, Hariharan (et al.)

  • CpG Islands Methylation Alterations in Cancer: Functionally Intriguing Security Locks, Useful Early Tumor Biomarkers

    Pages 53-62

    Loi, Eleonora (et al.)

  • Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders

    Pages 63-102

    Rani, Harsha (et al.)

  • DNA Methylation in Neuronal Development and Disease

    Pages 103-140

    Bruggeman, Emily C. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-14792-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-030-14791-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The DNA, RNA, and Histone Methylomes
Editors
  • Stefan Jurga
  • Jan Barciszewski
Series Title
RNA Technologies
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-14792-1
DOI
10.1007/978-3-030-14792-1
Hardcover ISBN
978-3-030-14791-4
Series ISSN
2197-9731
Edition Number
1
Number of Pages
XI, 624
Number of Illustrations
21 b/w illustrations, 57 illustrations in colour
Topics