Editors:
- Focuses on understanding the negative impact of hypoxia in cancer progression
- Describes how hypoxia promotes key events that lead to cancer metastasis
- Provides current approaches used clinically and pre-clinically to identify and target hypoxic cancer cells
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1136)
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions.
Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments.This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
Editors and Affiliations
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Breast and Ovarian Cancer Program, Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, USA
Daniele M. Gilkes
About the editor
Assistant Professor of Oncology
Assistant Professor Chemical and Molecular Engineering
Johns Hopkins University School of Medicine
Baltimore, Maryland
Jayne Koskinas Ted Giovanis Foundation for Health and Policy Partnership
Daniele Gilkes earned her MS in engineering from the University of Florida and her PhD in cancer biology from the University of South Florida. She is currently an assistant professor in the departments of Oncology as well as Chemical and Molecular Engineering at the Johns Hopkins University School of Medicine. Her research goal is to develop a breast cancer research program which utilizes new technologies that can rapidly advance our understanding of how the microenvironment, in particular hypoxia and hypoxia-induced genetic changes, promote breast cancer metastasis. The overall objective is to identify therapeutic strategies that focus on metastasis treatment and prevention strategies for breast cancer patients.
Current Research
Seeking to understand the timing and requirements for metastasis.
Using both mathematics and cancer biology to chart the process of metastasis.
These innovate cross-disciplinary studies will accelerate our understanding of metastasis and guide new therapy development to prevent metastasis in breast cancer survivors.
Bibliographic Information
Book Title: Hypoxia and Cancer Metastasis
Editors: Daniele M. Gilkes
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-12734-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-12733-6Published: 27 June 2019
Softcover ISBN: 978-3-030-12736-7Published: 15 August 2020
eBook ISBN: 978-3-030-12734-3Published: 14 June 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 160
Number of Illustrations: 1 b/w illustrations, 16 illustrations in colour
Topics: Cancer Research, Human Genetics, Molecular Medicine, Cell Biology