Thymus Transcriptome and Cell Biology

Editors: Passos, Geraldo A. (Ed.)

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  • This book focuses on a challenging field in biomedicine that is the genetic control of central immune tolerance
  • The volume brings together current knowledge on transcriptome and cell biology of an organ implicated in the control of immune homeostasis in body (thymus)
  • It also brings knowledge on the thymus through the functional genomics perspective
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  • ISBN 978-3-030-12040-5
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Hardcover $219.99
price for USA in USD
  • ISBN 978-3-030-12039-9
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About this book

This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity.

The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.

About the authors

Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. During several years he worked in close collaboration in the microarray laboratory at Centre d´Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then in the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus.  He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil). He is the coordinator of the Molecular Immunogenetics Group. He was the adviser of two PhD theses awarded by Ministry of Education/CAPES: in 2008, one of his students received the CAPES Thesis Award and in 2010, another student received the distinction CAPES Thesis Honor in Genetics.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance

    Geenen, Vincent (et al.)

    Pages 1-18

  • Thymus Ontogeny and Development

    Muñoz, J. J. (et al.)

    Pages 19-34

  • The Ins and Outs of Thymic Epithelial Cell Differentiation and Function

    Matsumoto, Minoru (et al.)

    Pages 35-65

  • T-Cell Development: From T-Lineage Specification to Intrathymic Maturation

    Yoganathan, Kogulan (et al.)

    Pages 67-115

  • Intrathymic Cell Migration: Implications in Thymocyte Development and T-Cell Repertoire Formation

    Mendes-da-Cruz, Daniella Arêas (et al.)

    Pages 117-148

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-030-12040-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-030-12039-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Thymus Transcriptome and Cell Biology
Editors
  • Geraldo A. Passos
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-12040-5
DOI
10.1007/978-3-030-12040-5
Hardcover ISBN
978-3-030-12039-9
Edition Number
1
Number of Pages
XVII, 318
Number of Illustrations
7 b/w illustrations, 23 illustrations in colour
Topics