Current Topics in Microbiology and Immunology

Activity-Based Protein Profiling

Editors: Cravatt, Benjamin F., Hsu, Ku-Lung, Weerapana, Eranthie (Eds.)

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  • Provides new insights into activity-based protein profiling (ABPP), which uses chemical probes to profile the functional state of enzymes in native biological systems
  • Focuses on the application of ABPP methodologies to processes relevant to microbiology and immunology
  • Helps readers identify the posttranslational regulatory mechanisms that modulate protein function
  •  
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-030-11143-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-030-11142-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.


About the authors

Benjamin F. Cravatt, Ph.D.

Department of Chemistry

The Scripps Research Institute

La Jolla, CA, USA

cravatt@scripps.edu

 

Ku-Lung Hsu Ph.D.

University of Virginia School of Medicine

Department of Chemistry

Charlottesville, VA, USA

kh4ch@virginia.edu

 

Eranthie Weerapana Ph.D.

Boston College

Merkert Chemistry

Chestnut Hill, MA, USA

eranthie@bc.edu

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Activity-Based Protein Profiling—Enabling Multimodal Functional Studies of Microbial Communities

    Whidbey, Christopher (et al.)

    Pages 1-21

  • Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles

    Sharifzadeh, Shabnam (et al.)

    Pages 23-48

  • Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria

    Patel, Hiren V. (et al.)

    Pages 49-72

  • Activity-Based Protein Profiling at the Host–Pathogen Interface

    Kovalyova, Yekaterina (et al.)

    Pages 73-91

  • Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens

    Peng, Tao (et al.)

    Pages 93-110

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-030-11143-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-030-11142-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Activity-Based Protein Profiling
Editors
  • Benjamin F. Cravatt
  • Ku-Lung Hsu
  • Eranthie Weerapana
Series Title
Current Topics in Microbiology and Immunology
Series Volume
420
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-11143-4
DOI
10.1007/978-3-030-11143-4
Hardcover ISBN
978-3-030-11142-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 417
Number of Illustrations
45 b/w illustrations, 70 illustrations in colour
Topics