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Activity-Based Protein Profiling

  • Book
  • © 2019

Overview

Editors:
  1. Benjamin F. Cravatt

    1. Department of Chemistry, The Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ku-Lung Hsu

    1. Department of Chemistry, University of Virginia, Charlottesville, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Eranthie Weerapana

    1. Department of Chemistry, Boston College, Chestnut Hill, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides new insights into activity-based protein profiling (ABPP), which uses chemical probes to profile the functional state of enzymes in native biological systems
  • Focuses on the application of ABPP methodologies to processes relevant to microbiology and immunology
  • Helps readers identify the posttranslational regulatory mechanisms that modulate protein function

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 420)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Activity-Based Protein Profiling—Enabling Multimodal Functional Studies of Microbial Communities

    • Christopher Whidbey, Aaron T. Wright
    Pages 1-21

  3. Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles

    • Shabnam Sharifzadeh, Joshua D. Shirley, Erin E. Carlson
    Pages 23-48

  4. Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria

    • Hiren V. Patel, Michael Li, Jessica C. Seeliger
    Pages 49-72

  5. Activity-Based Protein Profiling at the Host–Pathogen Interface

    • Yekaterina Kovalyova, Stavroula K. Hatzios
    Pages 73-91

  6. Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens

    • Tao Peng, Howard C. Hang
    Pages 93-110

  7. How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling

    • Gerbrand J. van der Heden van Noort, Huib Ovaa
    Pages 111-130

  8. ABPP and Host–Virus Interactions

    • Geneviève F. Desrochers, John Paul Pezacki
    Pages 131-154

  9. Activity-Based Protein Profiling for the Study of Parasite Biology

    • Henry J. Benns, Edward W. Tate, Matthew A. Child
    Pages 155-174

  10. Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling

    • Adam L. Borne, Tao Huang, Rebecca L. McCloud, Boobalan Pachaiyappan, Timothy N. J. Bullock, Ku-Lung Hsu
    Pages 175-210

  11. Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics

    • Ilsa T. Kirby, Michael S. Cohen
    Pages 211-231

  12. Development of Activity-Based Proteomic Probes for Protein Citrullination

    • Venkatesh V. Nemmara, Paul R. Thompson
    Pages 233-251

  13. Recent Advances in Activity-Based Protein Profiling of Proteases

    • Suravi Chakrabarty, Jan Pascal Kahler, Merel A. T. van de Plassche, Roeland Vanhoutte, Steven H. L. Verhelst
    Pages 253-281

  14. Opportunities for Lipid-Based Probes in the Field of Immunology

    • Sebastiaan T. A. Koenders, Berend Gagestein, Mario van der Stelt
    Pages 283-319

  15. Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases

    • Fumihiro Ishikawa, Genzoh Tanabe, Hideaki Kakeya
    Pages 321-349

  16. Target Identification of Bioactive Covalently Acting Natural Products

    • Daniel K. Nomura, Thomas J. Maimone
    Pages 351-374

  17. Applications of Reactive Cysteine Profiling

    • Keriann M. Backus
    Pages 375-417
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Keywords

About this book

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.


Editors and Affiliations

  • Department of Chemistry, The Scripps Research Institute, La Jolla, USA

    Benjamin F. Cravatt

  • Department of Chemistry, University of Virginia, Charlottesville, USA

    Ku-Lung Hsu

  • Department of Chemistry, Boston College, Chestnut Hill, USA

    Eranthie Weerapana

About the editors

Benjamin F. Cravatt, Ph.D.

Department of Chemistry

The Scripps Research Institute

La Jolla, CA, USA

cravatt@scripps.edu

 

Ku-Lung Hsu Ph.D.

University of Virginia School of Medicine

Department of Chemistry

Charlottesville, VA, USA

kh4ch@virginia.edu

 

Eranthie Weerapana Ph.D.

Boston College

Merkert Chemistry

Chestnut Hill, MA, USA

eranthie@bc.edu

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