Mechanisms of Drug Resistance in Cancer Therapy
Editors: Mandalà, Mario, Romano, Emanuela (Eds.)
Free Preview- Gives an updated overview on the possible reasons of failure of new and promising therapeutic opportunities
- Provides extensive discussions of issues including pharmacodynamic and pharmacokinetic mechanisms of resistance, alterations in the drug target, activation of prosurvival pathways, ineffective induction of cell death, and plasticity of microenvironment
- Covers the diverse perspectives of basic scientists, clinical pharmacologists and clinicians
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- About this book
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A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.
- Table of contents (15 chapters)
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Molecular and Pharmacological Mechanisms of Drug Resistance:An Evolving Paradigm
Pages 1-12
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Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival
Pages 13-30
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Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies
Pages 31-61
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Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer
Pages 63-89
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Mechanisms of Drug Resistance in Melanoma
Pages 91-108
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Table of contents (15 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mechanisms of Drug Resistance in Cancer Therapy
- Editors
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- Mario Mandalà
- Emanuela Romano
- Series Title
- Handbook of Experimental Pharmacology
- Series Volume
- 249
- Copyright
- 2018
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-10507-5
- DOI
- 10.1007/978-3-030-10507-5
- Hardcover ISBN
- 978-3-030-10506-8
- Series ISSN
- 0171-2004
- Edition Number
- 1
- Number of Pages
- VIII, 297
- Number of Illustrations
- 1 b/w illustrations, 31 illustrations in colour
- Topics
