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Handbook of Experimental Pharmacology

Mechanisms of Drug Resistance in Cancer Therapy

Editors: Mandalà, Mario, Romano, Emanuela (Eds.)

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  • Gives an updated overview on the possible reasons of failure of new and promising therapeutic opportunities
  • Provides extensive discussions of issues including pharmacodynamic and pharmacokinetic mechanisms of resistance, alterations in the drug target, activation of prosurvival pathways, ineffective induction of cell death, and plasticity of microenvironment
  • Covers the diverse perspectives of basic scientists, clinical pharmacologists and clinicians
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  • ISBN 978-3-030-10507-5
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Hardcover $179.99
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  • ISBN 978-3-030-10506-8
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About this book

A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • Molecular and Pharmacological Mechanisms of Drug Resistance:An Evolving Paradigm

    Pages 1-12

    Colmegna, Benedetta (et al.)

  • Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival

    Pages 13-30

    Tang, Huifang (et al.)

  • Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies

    Pages 31-61

    Croci, Diego O. (et al.)

  • Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer

    Pages 63-89

    Facchinetti, Francesco (et al.)

  • Mechanisms of Drug Resistance in Melanoma

    Pages 91-108

    Winder, Matthew (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-030-10507-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-030-10506-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Drug Resistance in Cancer Therapy
Editors
  • Mario Mandalà
  • Emanuela Romano
Series Title
Handbook of Experimental Pharmacology
Series Volume
249
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-10507-5
DOI
10.1007/978-3-030-10507-5
Hardcover ISBN
978-3-030-10506-8
Series ISSN
0171-2004
Edition Number
1
Number of Pages
VIII, 297
Number of Illustrations
1 b/w illustrations, 31 illustrations in colour
Topics

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