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Advances in Experimental Medicine and Biology

Cholesterol Modulation of Protein Function

Sterol Specificity and Indirect Mechanisms

Editors: Rosenhouse-Dantsker, Avia, Bukiya, Anna N. (Eds.)

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  • Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein functionContributors are well-known experts in their fields and provide international perspectiveResearch will be invaluable across several areas from biochemistry to nutrition

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eBook $139.00
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  • ISBN 978-3-030-04278-3
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Hardcover $179.99
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  • ISBN 978-3-030-04277-6
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About this book

In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed.

This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions.  In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function.

The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.

About the authors

Avia Rosenhouse-Dantsker, D.Sc., is a Clinical Assistant Professor at the University of Illinois at Chicago. Her research background ranges from quantum theory and computational biology to biophysical chemistry, molecular biology and electrophysiology. Her current research employs experimental and computational approaches to elucidate structural and functional mechanisms of protein modulation with a special emphasis on the modulation of ion channels by lipids (e.g. cholesterol, phosphoinositides, and others). Dr. Rosenhouse-Dantsker is a member of the Biophysical Society and the American Society for Biochemistry and Molecular Biology. She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.

Anna N. Bukiya, Ph.D., is an Associate Professor at the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center. Her scientific interests lie in the field of lipid modulation of ionic currents and ion channel sensitivity to alcohol starting from in utero development and spanning into adulthood. Current studies employ an array of computational, biochemical, electrophysiological, and integrative approaches. Dr. Anna Bukiya is a member of the Biophysical Society, and the American Society for Pharmacology and Experimental Therapeutics (Division of Cardiovascular Pharmacology). She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Chirality Effect on Cholesterol Modulation of Protein Function

    Pages 3-19

    Belani, Jitendra D.

  • A Critical Analysis of Molecular Mechanisms Underlying Membrane Cholesterol Sensitivity of GPCRs

    Pages 21-52

    Jafurulla, Md. (et al.)

  • Regulation of BK Channel Activity by Cholesterol and Its Derivatives

    Pages 53-75

    Bukiya, Anna N. (et al.)

  • Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K+ Channels

    Pages 77-95

    Barbera, Nicolas (et al.)

  • Cholesterol Effects on the Physical Properties of Lipid Membranes Viewed by Solid-state NMR Spectroscopy

    Pages 99-133

    Molugu, Trivikram R. (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-030-04278-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-030-04277-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cholesterol Modulation of Protein Function
Book Subtitle
Sterol Specificity and Indirect Mechanisms
Editors
  • Avia Rosenhouse-Dantsker
  • Anna N. Bukiya
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1115
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-04278-3
DOI
10.1007/978-3-030-04278-3
Hardcover ISBN
978-3-030-04277-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 197
Number of Illustrations
12 b/w illustrations, 33 illustrations in colour
Topics