Editors:
- Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function
- Contributors are well-known experts in their fields and provide international perspective
- Research will be invaluable across several areas from biochemistry to nutrition
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1115)
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Table of contents (9 chapters)
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Front Matter
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Sterol Specificity in Modulating Protein Function
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Front Matter
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Indirect Modulation of Protein Function by Cholesterol
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Front Matter
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Back Matter
About this book
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed.
This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Editors and Affiliations
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Department of Chemistry, University of Illinois, Chicago, USA
Avia Rosenhouse-Dantsker
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The University of Tennessee Health Science Center, Memphis, USA
Anna N. Bukiya
About the editors
Avia Rosenhouse-Dantsker, D.Sc., is a Clinical Assistant Professor at the University of Illinois at Chicago. Her research background ranges from quantum theory and computational biology to biophysical chemistry, molecular biology and electrophysiology. Her current research employs experimental and computational approaches to elucidate structural and functional mechanisms of protein modulation with a special emphasis on the modulation of ion channels by lipids (e.g. cholesterol, phosphoinositides, and others). Dr. Rosenhouse-Dantsker is a member of the Biophysical Society and the American Society for Biochemistry and Molecular Biology. She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.
Anna N. Bukiya, Ph.D., is an Associate Professor at the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center. Her scientific interests lie in the field of lipid modulation of ionic currents and ion channel sensitivity to alcohol starting from in utero development and spanning into adulthood. Current studies employ an array of computational, biochemical, electrophysiological, and integrative approaches. Dr. Anna Bukiya is a member of the Biophysical Society, and the American Society for Pharmacology and Experimental Therapeutics (Division of Cardiovascular Pharmacology). She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.
Bibliographic Information
Book Title: Cholesterol Modulation of Protein Function
Book Subtitle: Sterol Specificity and Indirect Mechanisms
Editors: Avia Rosenhouse-Dantsker, Anna N. Bukiya
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-04278-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-04277-6Published: 12 February 2019
eBook ISBN: 978-3-030-04278-3Published: 16 January 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: X, 197
Number of Illustrations: 12 b/w illustrations, 33 illustrations in colour
Topics: Proteomics, Protein Science, Membrane Biology, Molecular Medicine