Contemporary Endocrinology

Congenital Hyperinsulinism

A Practical Guide to Diagnosis and Management

Editors: De León-Crutchlow, Diva D., Stanley, Charles A. (Eds.)

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  • A practical guide for diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI)
  • Discusses the diagnosis and medical and surgical management of diazoxide-responsive, diazoxide-unresponsive and syndromic HI
  • A valuable resource for pediatric endocrinologists, general pediatricians and neonatologists
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eBook $84.99
price for USA in USD
  • ISBN 978-3-030-02961-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $109.99
price for USA in USD
About this book

This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter.
Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.

About the authors

Diva D. De León-Crutchlow, MD, MSCE, Associate Professor of Pediatrics, Chief, Division of Endocrinology and Diabetes, Director, Congenital Hyperinsulinism Center, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA


Charles A. Stanley, MD, Emeritus Professor of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-3-030-02961-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $109.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Congenital Hyperinsulinism
Book Subtitle
A Practical Guide to Diagnosis and Management
Editors
  • Diva D. De León-Crutchlow
  • Charles A. Stanley
Series Title
Contemporary Endocrinology
Copyright
2019
Publisher
Humana Press
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-02961-6
DOI
10.1007/978-3-030-02961-6
Hardcover ISBN
978-3-030-02960-9
Series ISSN
2523-3785
Edition Number
1
Number of Pages
XV, 165
Number of Illustrations
10 b/w illustrations, 12 illustrations in colour
Topics