Current Topics in Microbiology and Immunology

HIV-1 Latency

Editors: Silvestri, Guido, Lichterfeld, Mathias (Eds.)

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  • Offers new insights into the fascinating area of HIV latency and persistence from multiple perspectives and scientific directions
  • Provides in-depth analyses of current concepts, paradigms and ideas that drive the HIV-1 cure agenda
  • Identifies areas that require specific emphasis in future studies
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eBook $119.00
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  • ISBN 978-3-030-02816-9
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Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-02815-2
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About this book

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.


About the authors

Guido Silvestri

Emory University School of Medicine, Atlanta, GA 30329, USA

gsilves@emory.edu


Mathias Lichterfeld

The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA

MLICHTERFELD@mgh.harvard.edu


Table of contents (9 chapters)

Table of contents (9 chapters)
  • Molecular Control of HIV and SIV Latency

    Darcis, Gilles (et al.)

    Pages 1-22

  • Assays to Measure Latency, Reservoirs, and Reactivation

    Siliciano, Janet D. (et al.)

    Pages 23-41

  • The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir

    Veenhuis, Rebecca T. (et al.)

    Pages 43-67

  • Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy

    Del Prete, Gregory Q. (et al.)

    Pages 69-109

  • SIV Latency in Macrophages in the CNS

    Gama, Lucio (et al.)

    Pages 111-130

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-030-02816-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-02815-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
HIV-1 Latency
Editors
  • Guido Silvestri
  • Mathias Lichterfeld
Series Title
Current Topics in Microbiology and Immunology
Series Volume
417
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-02816-9
DOI
10.1007/978-3-030-02816-9
Hardcover ISBN
978-3-030-02815-2
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 248
Topics