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Springer Theses

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Authors: de Paiva, Raphael

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  • Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil 
  • Presents an innovative approach, using gold chemistry to target zinc finger proteins
  • Explores the use of Travelling-Wave Ion Mobility coupled with Mass Spectrometry, and X-ray Absorption Spectroscopy to obtain structural information on the Gold adducts
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  • ISBN 978-3-030-00853-6
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About this book

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Table of contents (6 chapters)

Table of contents (6 chapters)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-030-00853-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-030-00852-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
Softcover $139.99
price for USA in USD
  • ISBN 978-3-030-13150-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-00853-6
DOI
10.1007/978-3-030-00853-6
Hardcover ISBN
978-3-030-00852-9
Softcover ISBN
978-3-030-13150-0
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXXIX, 151
Number of Illustrations
62 b/w illustrations, 38 illustrations in colour
Topics

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