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Advances in Experimental Medicine and Biology

Prefoldins: the new chaperones

Editors: Djouder, Nabil (Ed.)

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  •  A comprehensive book on molecular chaperones of the prefoldin family   Several contributions from top researches in the prefoldin field   Dedicated section to the URI prefoldin-like complex

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eBook $119.00
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  • ISBN 978-3-030-00737-9
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Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-00736-2
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  • Usually dispatched within 3 to 5 business days.
About this book

This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease.   This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined.

This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.

About the authors

Nabil Djouder obtained his PhD in Molecular Pharmacology from the University of Strasbourg (France) and the University of Freiburg (Germany). In 2001 he moved to Basel (Switzerland) as a postdoctoral research fellow and joined the laboratory of W. Krek at the Novartis Friedrich Miescher Institute. In 2003 he became a member of the Competence Centre for Systems Physiology and Metabolic Diseases (CCSPMD) and in September 2009 he joined the CNIO as a Principal Investigator establishing his group in the field of Growth factors, Metabolism and Cancer.

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Functional Contributions of Prefoldin to Gene Expression

    Pages 1-10

    Payán-Bravo, Laura (et al.)

  • Prefoldins in Archaea

    Pages 11-23

    Lim, Samuel (et al.)

  • Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease

    Pages 25-36

    Gauthier, Marie-Soleil (et al.)

  • The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex

    Pages 37-72

    Lynham, Jeffrey (et al.)

  • Advances on the Structure of the R2TP/Prefoldin-like Complex

    Pages 73-83

    Muñoz-Hernández, Hugo (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-030-00737-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.99
price for USA in USD
  • ISBN 978-3-030-00736-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Prefoldins: the new chaperones
Editors
  • Nabil Djouder
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1106
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-00737-9
DOI
10.1007/978-3-030-00737-9
Hardcover ISBN
978-3-030-00736-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 135
Number of Illustrations
3 b/w illustrations, 36 illustrations in colour
Topics