Gene Therapy of Cancer
Methods and Protocols
Editors: Walther, Wolfgang, Stein, Ulrike S. (Eds.)
Free Preview- Describes a broad array of different strategies and methods such as for immunogene therapy, antitumor vaccination, oncolytic virotherapy, and suicide gene therapy
- Provides state-of-the-art protocols and overview chapters for cancer gene therapy, along with step-by-step procedures and instructions for gene therapeutic strategies, including notes and tips for troubleshooting to avoid pitfalls
- Explores nonviral and viral vectors and relevant gene transfer/delivery systems
- Includes methods and backgrounds of experimental and clinical gene therapy approaches
- Covers the important issue of vector design and vector production for clinical applications
- Features the current regulatory and ethical aspects in translating experimental approaches into clinical application of gene therapy to patients
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- About this book
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Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. Gene Therapy of Cancer: Methods and Protocols, Second Edition fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting edge and authoritative, Gene Therapy of Cancer: Methods and Protocols, Second Edition is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.
- Reviews
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From the reviews of the second edition:
“This book, authored by a number of prominent researchers in the field … provides an overview of recent ground-breaking experimental and clinical concepts and protocols in cancer gene therapy. … the editors and authors are to be commended for producing a well-organised, authoritative and succinct coverage of the vast area of gene therapy protocols. The materials are relevant, easy-to-follow and well-presented with good illustrations. Without doubt it will serve as a useful resource for those interested in this field, both scientists and clinicians … .” (Han Hsi Wong and Yaohe Wang, Human Genetics, Vol. 128, July, 2010)
- Table of contents (35 chapters)
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The Development of Gene Therapy: From Monogenic Recessive Disorders to Complex Diseases Such as Cancer
Pages 5-54
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Designing Adenoviral Vectors for Tumor-Specific Targeting
Pages 56-74
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Analysis of HSV Oncolytic Virotherapy in Organotypic Cultures
Pages 75-86
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Use of Minicircle Plasmids for Gene Therapy
Pages 87-104
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Transposable Elements as Plasmid-Based Vectors for Long-Term Gene Transfer into Tumors
Pages 105-116
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Table of contents (35 chapters)
- Download Preface 1 PDF (80.8 KB)
- Download Sample pages 1 PDF (323.7 KB)
- Download Table of contents PDF (96.5 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Gene Therapy of Cancer
- Book Subtitle
- Methods and Protocols
- Editors
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- Wolfgang Walther
- Ulrike S. Stein
- Series Title
- Methods in Molecular Biology
- Series Volume
- 542
- Copyright
- 2009
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- eBook ISBN
- 978-1-59745-561-9
- DOI
- 10.1007/978-1-59745-561-9
- Hardcover ISBN
- 978-1-934115-85-5
- Softcover ISBN
- 978-1-61737-946-8
- Series ISSN
- 1064-3745
- Edition Number
- 2
- Number of Pages
- XIV, 738
- Number of Illustrations
- 89 b/w illustrations, 8 illustrations in colour
- Topics
